Influence of the endocrine environment on herpes virus infection in rat lacrimal gland acinar cells.
Influence of the endocrine environment on herpes virus infection in rat lacrimal gland acinar cells.
复制标题
内分泌环境对大鼠泪腺腺泡细胞疱疹病毒感染的影响。
DOI：
10.1007/978-1-4615-2417-5_33
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发表时间：
1994
影响因子：
--
通讯作者：
Sullivan,DA
中科院分区：
文献类型：
--
作者：
Huang,Z;Lambert,RW;Wickham,LA;Sullivan,DA
干燥性角膜结膜炎是世界上最常见的干燥性角膜结膜炎之一。1这种疾病是一种极其复杂的自身免疫性疾病，几乎只发生在女性中，并且涉及泪液组织的进行性、免疫介导的破坏和随后的干眼。2干燥综合征的病因尚不清楚，尽管最近的研究表明病毒感染和激素作用可能在这种自身免疫性疾病的发病机制和/或表达中起重要作用。3，4因此，疱疹病毒的原发性感染（例如Epstein-Barr病毒、巨细胞病毒、疱疹病毒-6）或逆转录病毒，可引起淋巴细胞积聚、免疫细胞活化和受影响的泪腺组织中明显的相关炎症。3，4此外，性类固醇可能：[a]影响干燥综合征中泪腺免疫病理学的发作和/或严重程度; 4和[B]潜在地改变受感染泪腺组织中的病毒活性，因为已知此类激素可调节疱疹病毒转录。5，6
Throughout the world, one of the greatest single causes of keratoconjuctivitis sicca is Sjögren’s syndrome:1this disease is an exceedingly complex autoimmune disorder, which occurs almost exclusively in females, and involves a progressive, immune-mediated destruction of lacrimal tissue and consequent dry eye.2The etiology of Sjögren’s sydrome is unclear, although recent research has suggested that viral infection and hormone action may play significant roles in the pathogenesis and/or expression of this autoimmune disease.3,4Thus, primary infection by herpes viruses (e.g. Epstein-Barr virus, cytomegalovirus, herpes virus-6), or retroviruses, may elicit the lymphocytic accumulation, immune cell activation and associated inflammation evident in affected lacrimal tissues.3,4Moreover, sex steroids may: [a] influence the onset and/or severity of lacrimal gland immunopathology in Sjögren’s syndrome;4and [b] potentially alter viral activity in infected lacrimal tissues, given that such hormones are known to modulate herpes virus transcription.5,6