Central and peripheral muscarinic actions of physostigmine and oxotremorine on avoidance responding of squirrel monkeys
Central and peripheral muscarinic actions of physostigmine and oxotremorine on avoidance responding of squirrel monkeys
复制标题
毒扁豆碱和氧化震颤素对松鼠猴回避反应的中枢和外周毒蕈碱作用
作者：
J. Witkin
通过比较阿托品和甲基拉托品逆转毒力斯的明、毒力斯的明激动剂氧tremorine或它们的四元类似物新斯的明和氧tremorine- m的作用，来评估中枢和外周毒蕈碱胆碱能受体参与胆碱酯酶抑制剂毒力斯的明的行为效应。在每个杠杆按压延迟电击20 s的计划下，回避行为保持不变；在没有反应的情况下，每隔5秒电击一次。累积剂量的芥子碱或氧tremorine产生与剂量相关的反应率降低，反应持续时间和休克递送率增加。新斯的明和奥曲莫林也有类似的效果。甲拉托品完全阻止了新斯的明和奥曲莫林- m对行为和副交感神经的影响，而本身没有任何行为影响。然而，甲基拉托品并没有改变毒豆碱或氧tremorine的行为效果。尽管阿托品单独给药时减少了回避反应，但阿托品可以防止外周表现以及蛇毒碱和氧甲羟碱的行为影响。这些结果表明，在松鼠猴中，中枢和外周毒蕈碱受体可能以一种冗余的方式起作用，以控制激动剂诱导的回避减少。当毒豆碱或氧甲酚与阿托品联合使用时，回避反应率增加到对照水平的180%。在用阿托品治疗的猴子中，在给予氧甲氧胺或蛇毒碱后，反应率增加可能反映了阿托品的非毒蕈碱作用，而被胆碱模拟物的存在所掩盖。
The involvement of central and peripheral muscarinic cholinergic receptors in the behavioral effects of the cholinesterase inhibitor physostigmine was evaluated by comparing the ability of atropine and methylatropine to reverse the effects of physostigmine, the muscarinic agonist oxotremorine, or their quaternary analogs neostigmine and oxotremorine-M. Avoidance behavior was maintained under a schedule in which every lever press postponed delivery of electric shock for 20 s; shock occurred every 5 s in the absence of responding. Cumulative doses of physostigmine or oxotremorine produced dose-related decreases in response rates, and increases in response durations and rates of shock delivery. Similar effects occurred with neostigmine and oxotremorine-M. Methylatropine completely prevented the behavioral and parasympathetic effects of neostigmine and oxotremorine-M without having any behavioral effects of its own. However, methylatropine did not alter the behavioral effects of physostigmine or oxotremorine. Atropine prevented the peripheral manifestations as well as the behavioral effects of physostigmine and oxotremorine even though atropine decreased avoidance responding when given alone. These results suggest that in squirrel monkeys, central and peripheral muscarinic receptors may function in a redundant manner to control agonist-induced decrements in avoidance. When physostigmine or oxotremorine was given in conjunction with atropine, rates of avoidance responding were increased to 180% of control levels. Response rate increases after administration of oxotremorine or physostigmine in monkeys treated with atropine may reflect a non-muscarinic action of atropine, unmasked by the presence of cholinomimetics.
三环类抗抑郁药和抗胆碱能药物对松鼠猴固定间隔反应的影响。
DOI：
--
发表时间：
1982
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
McKearney,JW
通讯作者：
McKearney,JW
氧化震颤素及其类似物的药理学特性。
影响因子：
6.1
作者：
Ringdahl,B;Jenden,DJ
通讯作者：
Jenden,DJ