Effects of typical and atypical antipsychotic drugs on maternal behavior in postpartum female rats
Effects of typical and atypical antipsychotic drugs on maternal behavior in postpartum female rats
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DOI：
10.1016/j.schres.2003.09.013
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发表时间：
2004-09-01
影响因子：
4.5
通讯作者：
Fleming, AS
中科院分区：
文献类型：
--
作者：
Li, M;Davidson, P;Fleming, AS
了解抗精神病药物 (APD) 对社会行为（例如母亲行为）的影响对于了解抗精神病药物的完整治疗范围和副作用很有价值。尽管之前的研究表明典型的抗精神病药物会损害母亲的行为，但非典型抗精神病药物的影响尚未得到系统的探索。本报告的目的是检查典型（氟哌啶醇，HAL）和几种非典型（氯氮平，CLZ；利培酮，RIS；喹硫平，QUE）抗精神病药物对雌性大鼠母性行为的影响。在产后第 6 天单次注射一系列剂量的 HAL、CLZ、RIS 或 QUE 后，在 24 小时内重复检查母亲的行为。所有抗精神病药物，无论是典型的还是非典型的，在临床相关剂量下，都会对母体行为的主动成分产生性质相似的破坏作用，例如幼崽接近、幼崽回收和筑巢。然而，HAL 造成了长时间的破坏，而 CLZ、RIS 和 QUE 则引起了早期发作但持续时间较短的破坏。此外，只有非典型抗精神病药物对护理行为表现出一定的抑制作用，这可能是由于所有非典型抗精神病药物都具有镇静副作用。当前一代非典型抗精神病药对母亲行为表现出与典型抗精神病药类似的破坏性影响。这种作用可能是抗精神病活性所固有的，也可能是副作用的反映。由于后者更有可能，因此这可能是未来抗精神病药物设计中要避免的效果。 (C) 2003 年，Elsevier B.V. 出版
Understanding the effects of antipsychotic drugs (APDs) on social behaviors such as maternal behavior is valuable for understanding the complete spectrum of therapeutic and side-effects of antipsychotics. Although previous studies have suggested that typical antipsychotics impair maternal behavior, the effects of the atypical antipsychotics have not been systematically explored. The purpose of the present report was to examine the effects of typical (haloperidol, HAL) and several atypical (clozapine, CLZ; risperidone, RIS; quetiapine, QUE) antipsychotics on maternal behavior in female rats. Maternal behaviors were examined repeatedly over a period of 24 h after a single injection of a range of doses of HAL, CLZ, RIS or QUE on Day 6 postpartum. All antipsychotic drugs, typical or atypical, elicited a qualitatively similar disruptive effect on the active components of maternal behavior such as pup approach, pup retrieval and nest building at clinically relevant doses. However, HAL caused a prolonged disruption, whereas CLZ, RIS and QUE induced an early onset but shorter duration disruption. In addition, only the atypical antipsychotics showed some inhibitory effects on nursing behavior, possibly due to sedative side-effects shared by all atypical antipsychotics. The current generation of atypical antipsychotics shows a disruptive influence on maternal behavior similar to that of the typical antipsychotics. This effect may be intrinsic to antipsychotic activity or may be reflective of a side-effect. Since the latter is more likely, this may be an effect to avoid in the design of future antipsychotics. (C) 2003 Published by Elsevier B.V.