Potentiation of GABAA receptors expressed in Xenopus oocytes by perfume and phytoncid
Potentiation of GABAA receptors expressed in Xenopus oocytes by perfume and phytoncid
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DOI：
10.1271/bbb.63.743
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发表时间：
1999-04-01
影响因子：
1.6
通讯作者：
Hamamoto, K
中科院分区：
文献类型：
--
作者：
Aoshima, H;Hamamoto, K
为研究香料和植物杀菌素对GABA（A）受体的影响，将从大鼠全脑中提取的mRNA注射到非洲爪蟾卵母细胞中表达离子型GABA（A）受体。精油、香料和植物杀菌素如叶醇、扁柏酚、蒎烯、丁香酚、香茅醇和香茅醛在低浓度GABA存在下增强这种反应（10和30 μ M），可能是因为它们与GABA（A）受体的增强位点结合，增加了GABA对受体的亲和力。类固醇和麻醉剂诱导抗焦虑、抗惊厥和镇静活性或麻醉作用，这些结果表明通过肺、皮肤或肠摄入香料或植物杀菌素通过离子型GABA（A）受体调节大脑中的神经传递并改变人类思维框架的可能性，就像酒精或烟草一样。
To study the effects of perfume and phytoncid on GABA(A) receptors, ionotropic GABA(A) receptors were expressed in Xenopus oocytes by injecting mRNAs that had been prepared from rat whole brain. Essential oil, perfume and such phytoncid as leaf alcohol, hinokitiol, pinene, eugenol, citronellol and citronellal potentiated the response in the presence of GABA at low concentrations (10 and 30 mu M), possibly because they bound to the potentiation-site in GABA(A) receptors and increased the affinity of GABA to the receptors, Since it is known that the potentiation of GABA(A) receptors by benzodiazepine, barbiturate, steroids and anesthetics induces the anxiolytic, anticonvulsant and sedative activity or anesthetic effect, these results suggest the possibility that the intake of perfume or phytoncid through the lungs, the skin or the intestines modulates the neural transmission in the brain through ionotropic GABA(A) receptors and changes the frame of the human mind, as alcohol or tobacco does.