Epigenomic and microRNA-mediated regulation in cartilage development, homeostasis, and osteoarthritis.
Epigenomic and microRNA-mediated regulation in cartilage development, homeostasis, and osteoarthritis.
复制标题
DOI：
10.1016/j.molmed.2011.11.005
复制
发表时间：
2012-02
影响因子：
13.6
通讯作者：
Marcu KB
中科院分区：
文献类型：
--
作者：
Goldring MB;Marcu KB
骨关节炎（OA）是一种受多种基因和环境因素影响的多因素疾病。软骨中软骨细胞基因控制的正常模式的改变促进OA的发生和进展。基因表达模式的稳定变化，与DNA序列的改变无关，通过表观遗传变化发生，包括DNA甲基化，组蛋白修饰和染色质结构的改变，以及通过microRNA（miRNA）介导的机制。此外，宿主修复受损软骨的能力反映在基因控制回路的改变中，表明组织稳态和OA疾病发病机制之间存在表观遗传和miRNA依赖性拔河。在此，我们总结了影响OA进展的表观遗传和miRNA介导的机制，并在此背景下为OA治疗提供潜在的治疗策略。
Osteoarthritis (OA) is a multifactorial disease subject to the effects of many genes and environmental factors. Alterations in the normal pattern of chondrocyte gene control in cartilage facilitate the onset and progression of OA. Stable changes in patterns of gene expression, not associated with alterations in DNA sequences, occur through epigenetic changes, including DNA methylation, histone modifications, and alterations in chromatin structure, as well as by microRNA (miRNA)-mediated mechanisms. Moreover, the ability of the host to repair damaged cartilage is reflected in alterations in gene control circuits, suggestive of an epigenetic and miRNA-dependent tug-of-war between tissue homeostasis and OA disease pathogenesis. Herein, we summarize epigenetic and miRNA-mediated mechanisms impacting on OA progression and in this context offer potential therapeutic strategies for OA treatment.
登录
查看更多内容
影响因子：
--
作者：
Dunn, Walter;DuRaine, Grayson;Reddi, A. Hari
通讯作者：
Reddi, A. Hari
影响因子：
--
作者：
Aigner, Thomas;Fundel, Katrin;Bartnik, Eckart
通讯作者：
Bartnik, Eckart
影响因子：
--
作者：
Akhtar, Nahid;Rasheed, Zafar;Ramamurthy, Sangeetha;Anbazhagan, Arivarasu N.;Voss, Frank R.;Haqqi, Tariq M.
通讯作者：
Haqqi, Tariq M.
影响因子：
--
作者：
Fukui, Naoshi;Ikeda, Yasuko;Ochi, Takahiro
通讯作者：
Ochi, Takahiro
影响因子：
--
作者：
Gagarina, Viktoria;Gabay, Odile;Dvir-Ginzberg, Mona;Lee, Eun Jin;Brady, Jillian K.;Quon, Michael J.;Hall, David J.
通讯作者：
Hall, David J.