Aromatic C–H Addition to Ketones: The Effect of Directing Groups
Aromatic C–H Addition to Ketones: The Effect of Directing Groups
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DOI：
10.1002/ejoc.201301115
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发表时间：
2013-10
影响因子：
2.8
通讯作者：
Xi‐Sha Zhang;Qi‐Lei Zhu;Fei-Xian Luo;Guihua Chen;Xin Wang;Zhangjie Shi
中科院分区：
文献类型：
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作者：
Xi‐Sha Zhang;Qi‐Lei Zhu;Fei-Xian Luo;Guihua Chen;Xin Wang;Zhangjie Shi
过渡金属催化的分子间C-H键直接加成到酮上的第一个例子是通过使用铑催化剂实现的。导向基团对反应活性有显著影响，空间位阻较大的导向基团能促进反应。此外，分子间氢键在稳定产物中起作用。喹啉衍生物的底物范围非常好。
The first example of the transition-metal-catalyzed direct intermolecular C–H bond addition to ketones was achieved by using a rhodium catalyst. A significant influence of the directing group on the reactivity was observed, and sterically more hindered directing groups could promote the reaction. In addition, intermolecular hydrogen bonding played a role in stabilizing the product. The substrate scope for the quinoline derivatives was very good.