Mechanisms of the regulation of the intestinal Na+/H+ exchanger NHE3.
Mechanisms of the regulation of the intestinal Na+/H+ exchanger NHE3.
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DOI：
10.1155/2010/238080
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发表时间：
2010
影响因子：
--
通讯作者：
Yun CC
中科院分区：
文献类型：
--
作者：
He P;Yun CC
Na ~+/H ~+交换器3（Na ~+/H ~+ exchanger type 3，NHE_3）的电中性交换是小肠和肾脏近端Na ~+吸收的主要过程。在过去的十年中，在NHE 3调节机制方面取得了重大进展。目前关于Na+/H+交换器调节的大量知识是基于哺乳动物Na+/H+交换器在Na+/H+交换器缺陷的成纤维细胞、肾上皮和肠上皮细胞中的异源表达。基于还原论者的方法，对NHE 3调节的理解已经大大推进。最近，已经使用缺乏一种或多种蛋白质的动物进行了体外研究的确认，但在某些情况下出现了意想不到的发现。本文就NHE 3在肠道腔膜中的调节及其功能的研究进展作一简要综述。
A major of Na+ absorptive process in the proximal part of intestine and kidney is electroneutral exchange of Na+ and H+ by Na+/H+ exchanger type 3 (NHE3). During the past decade, significant advance has been achieved in the mechanisms of NHE3 regulation. A bulk of the current knowledge on Na+/H+ exchanger regulation is based on heterologous expression of mammalian Na+/H+ exchangers in Na+/H+ exchanger deficient fibroblasts, renal epithelial, and intestinal epithelial cells. Based on the reductionist's approach, an understanding of NHE3 regulation has been greatly advanced. More recently, confirmations of in vitro studies have been made using animals deficient in one or more proteins but in some cases unexpected findings have emerged. The purpose of this paper is to provide a brief overview of recent progress in the regulation and functions of NHE3 present in the luminal membrane of the intestinal tract.
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影响因子：
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期刊：
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