Genetics and Epigenetics: Implications for the Life Course of Gestational Diabetes.
Genetics and Epigenetics: Implications for the Life Course of Gestational Diabetes.
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DOI：
10.3390/ijms24076047
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发表时间：
2023-03-23
影响因子：
5.6
通讯作者：
Lowe, William L.
中科院分区：
文献类型：
--
作者：
Lowe, William L.
关键词：
妊娠期糖尿病（GDM）是妊娠最常见的并发症之一，影响多达六分之一的妊娠。它与母亲和胎儿的短期和长期不良后果有关，对受影响妇女的生命历程具有重要意义。遗传学和表观遗传学的进展不仅为GDM的病理生理学提供了新的见解，而且还为识别产后心脏代谢疾病高风险妇女提供了新的方法。GDM和2型糖尿病在病理生理上有相似之处，这表明它们在遗传结构上也有相似之处。候选基因和全基因组关联研究已经确定了GDM和2型糖尿病之间共有的易感基因。尽管有这些相似之处，与2型糖尿病相比，MTNR1B对GDM的影响要大得多，并且编码己糖激酶的HKDC1与GDM（而非2型糖尿病）的关联表明GDM的遗传结构存在一些差异。遗传风险评分在鉴别有GDM病史的女性是否会发展为2型糖尿病方面显示出一定的功效。表观遗传变化（包括DNA甲基化和循环microrna）与GDM的关系也被研究。靶向和全表观基因组方法已被用于鉴定妊娠早期、中期和晚期收集的与GDM相关的循环血细胞中的DNA甲基化。妊娠早期的DNA甲基化能够识别进展为GDM的妇女，而妊娠26-30周采集的血液中的DNA甲基化在临床因素单独识别有进展为产后糖耐量异常风险的妇女的能力上有所改善。最后，循环microrna和长链非编码rna存在于妊娠早期或中期，并与GDM相关。microrna也被证明在预测GDM的发展及其长期心脏代谢并发症方面是有效的。迄今为止进行的研究已经证明了遗传和表观遗传技术影响临床护理的潜力，尽管仍有许多工作要做。
Gestational diabetes (GDM) is one of the most common complications of pregnancy, affecting as many as one in six pregnancies. It is associated with both short- and long-term adverse outcomes for the mother and fetus and has important implications for the life course of affected women. Advances in genetics and epigenetics have not only provided new insight into the pathophysiology of GDM but have also provided new approaches to identify women at high risk for progression to postpartum cardiometabolic disease. GDM and type 2 diabetes share similarities in their pathophysiology, suggesting that they also share similarities in their genetic architecture. Candidate gene and genome-wide association studies have identified susceptibility genes that are shared between GDM and type 2 diabetes. Despite these similarities, a much greater effect size for MTNR1B in GDM compared to type 2 diabetes and association of HKDC1, which encodes a hexokinase, with GDM but not type 2 diabetes suggest some differences in the genetic architecture of GDM. Genetic risk scores have shown some efficacy in identifying women with a history of GDM who will progress to type 2 diabetes. The association of epigenetic changes, including DNA methylation and circulating microRNAs, with GDM has also been examined. Targeted and epigenome-wide approaches have been used to identify DNA methylation in circulating blood cells collected during early, mid-, and late pregnancy that is associated with GDM. DNA methylation in early pregnancy had some ability to identify women who progressed to GDM, while DNA methylation in blood collected at 26–30 weeks gestation improved upon the ability of clinical factors alone to identify women at risk for progression to abnormal glucose tolerance post-partum. Finally, circulating microRNAs and long non-coding RNAs that are present in early or mid-pregnancy and associated with GDM have been identified. MicroRNAs have also proven efficacious in predicting both the development of GDM as well as its long-term cardiometabolic complications. Studies performed to date have demonstrated the potential for genetic and epigenetic technologies to impact clinical care, although much remains to be done.
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影响因子：
64.8
作者：
Baek, Daehyun;Villen, Judit;Shin, Chanseok;Camargo, Fernando D.;Gygi, Steven P.;Bartel, David P.
通讯作者：
Bartel, David P.
影响因子：
16.2
作者：
Canouil M;Khamis A;Keikkala E;Hummel S;Lobbens S;Bonnefond A;Delahaye F;Tzala E;Mustaniemi S;Vääräsmäki M;Jarvelin MR;Sebert S;Kajantie E;Froguel P;Andrew T
通讯作者：
Andrew T
DOI：
10.1016/0002-9378(93)90358-p
发表时间：
1993-04-01
影响因子：
9.8
作者：
COUSTAN, DR;CARPENTER, MW;CARR, SR
通讯作者：
CARR, SR
影响因子：
7.2
作者：
Blatt, Amy J.;Nakamoto, Jon M.;Kaufman, Harvey W.
通讯作者：
Kaufman, Harvey W.
影响因子：
4.2
作者：
DeForest, Natalie;Majithia, Amit R.
通讯作者：
Majithia, Amit R.