NMDA receptor signaling: death or survival?
NMDA receptor signaling: death or survival?
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DOI：
10.1007/s11515-011-1187-6
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发表时间：
2011-12
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谷氨酸诱导的神经元损伤主要是由N-甲基-D-天冬氨酸（NMDA）受体过度激活引起的。相反，正常的生理脑功能和神经元存活需要足够的NMDA受体激活。研究表明，NMDA受体诱导的神经元死亡或存活是通过不同的NMDA受体亚群触发不同的细胞内信号通路介导的。在这里，我们讨论的最新进展，在神经元保护的NMDA受体的特性，强调亚单位的具体作用，这有助于时空分布，亚细胞定位和不同的通道特性的NMDA受体。
Glutamate-induced neuronal damage is mainly caused by overactivation of N-methyl-D-aspartate (NMDA) receptors. Conversely, normal physiological brain function and neuronal survival require adequate activation of NMDA receptors. Studies have revealed that NMDA receptor-induced neuronal death or survival is mediated through distinct subset of NMDA receptors triggering different intracellular signaling pathways. Here we discuss recent advances in the characterization of NMDA receptors in neuronal protection, emphasizing subunit-specific role, which contributes to temporal-spatial distribution, subcellular localization and diverse channel properties of NMDA receptors.