Neurohumoral factors during transition from left ventricular hypertrophy to failure in Dahl salt-sensitive rats.
Neurohumoral factors during transition from left ventricular hypertrophy to failure in Dahl salt-sensitive rats.
复制标题
达尔盐敏感大鼠从左心室肥厚到衰竭转变过程中的神经体液因素。
DOI：
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
S. Sasayama
中科院分区：
文献类型：
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作者：
M. Inoko;Y. Kihara;S. Sasayama
采用Dahl盐敏感大鼠（DS） CHF模型，研究左心室（LV）肥厚到充血性心力衰竭（CHF）过程中β -肾上腺素能刺激的正性肌力效应（PIE）的降低与全身及组织神经体液因子水平的关系。对照研究在年龄匹配的达尔耐盐（DR）大鼠中进行。DS大鼠CHF期血浆房钠肽（ANP）和去甲肾上腺素（NE）水平较同龄DR大鼠明显升高，心肌NE水平降低。另一方面，在肥厚期，尽管心肌NE浓度降低，但血浆ANP或NE水平在两株之间无显著差异。异丙肾上腺素诱导的PIE在代偿性左室肥厚期降低，随后在CHF期进一步降低。结果清楚地表明，心肌β -肾上腺素能脱敏伴局部交感神经调节异常始于机械代偿性左室肥厚，先于全身拟交感神经激素的增加。
The relationship between the reduction in the positive inotropic effects (PIE) of beta-adrenergic stimulation and the level of systemic and tissue neurohumoral factors during the course from left ventricular (LV) hypertrophy to congestive heart failure (CHF) was studied in Dahl salt-sensitive rat (DS) CHF model. Control studies were performed in age-matched Dahl salt-resistant (DR) rats. In DS rats at CHF stage, plasma atrial natriuretic peptide (ANP) and norepinephrine (NE) levels were elevated markedly and myocardial NE level was decreased compared with those in the age-matched DR rats. On the other hand, at the hypertrophy stage, we observed no significant differences in plasma ANP or NE level between the two strains in spite of decrease in myocardial NE concentration. The PIE induced by isoproterenol was reduced at the stage of compensatory LV hypertrophy, which was followed by further reduction of PIE at CHF stage. The results distinctively indicate that beta-adrenergic desensitization in the myocardium which was accompanied with the abnormalities in local sympathoneuronal regulation begins during mechanically compensated LV hypertrophy and precedes systemic augmentation of sympathomimetic hormones.