Cancer incidence among a cohort of smokeless tobacco users (United States)
Cancer incidence among a cohort of smokeless tobacco users (United States)
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DOI：
10.1007/s10552-005-0247-0
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发表时间：
2005-11-01
影响因子：
2.3
通讯作者：
Howard, G
中科院分区：
文献类型：
--
作者：
Accortt, NA;Waterbor, JW;Howard, G
目标：无烟烟草（ST）的使用仍然是某些美国人群中一种普遍的烟草使用形式。本文的目的是阐明其在癌症发展中的作用。方法：利用美国人口前瞻性队列的数据，我们将 6779 名 45-75 岁的受试者分为 ST 使用者或非 ST 使用者。根据吸烟状况对受试者进行进一步分层，以区分“专属”无烟烟草使用者 (n=414) 与从不吸烟 (n=2979)。 结果：在该队列中，专属无烟烟草使用与男性（风险比=0.8，95% CI：0.4，1.6）或女性（HR=1.2，95% CI：0.7-2.1）或口腔癌症发病率增加无关。癌症（标准化发病率 = 30, 95% CI: 3, 95）。在男性联合使用者（未对女性联合使用进行分析）中，没有观察到无烟烟草和吸烟之间对主要癌症的协同作用。 结论：与众所周知的吸烟有害影响相比，无烟烟草的使用并没有显着增加癌症发病率高于不吸烟者的癌症发病风险，特别是在男性中。尽管不鼓励以任何形式使用烟草，但我们的数据表明，使用无烟烟草的癌症风险比吸烟要低得多。
Objective: Smokeless tobacco (ST) use remains a prevalent form of tobacco use among certain US populations. The purpose of this paper is to clarify its role in cancer development.Methods: Using data from a prospective cohort of the US population, we categorized 6779 subjects 45-75 years of age as ST users or non-ST users. Subjects were further stratified by cigarette smoking status in order to differentiate 'exclusive' ST users (n=414) from never tobacco users (n=2979).Results: In this cohort, exclusive ST use was not associated with increased incidence of all cancer in males (hazard ratio=0.8, 95% CI: 0.4, 1.6) or females (HR=1.2, 95% CI: 0.7-2.1) or oral cancer (standardized incidence ratio=30, 95% CI: 3, 95). No synergistic effect was observed between ST and cigarette smoking among male combined users (females were not analyzed for combined use) for the major cancers.Conclusions: In contrast to the well-known deleterious effects of cigarette smoking, ST use did not substantially increase the risk for cancer incidence above that of non-tobacco users, particularly among males. Although the use of tobacco in any form is to be discouraged, our data suggests that cancer risks are much lower from ST use than from cigarette smoking.