Organocatalytic Enantioselective Decarboxylative Addition of Malonic Acids Half Thioesters to Isatins
Organocatalytic Enantioselective Decarboxylative Addition of Malonic Acids Half Thioesters to Isatins
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DOI：
10.1002/adsc.201100410
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发表时间：
2011-11-01
影响因子：
5.4
通讯作者：
Shibata, Norio
中科院分区：
文献类型：
--
作者：
Hara, Noriyuki;Nakamura, Shuichi;Shibata, Norio
使用方酰胺催化剂对丙二酸半硫酯进行有机催化对映选择性脱羧加成至靛红，使产物具有高对映选择性。这些产品是合成3-取代3-羟基-2-羟吲哚衍生物的关键中间体。 (-)-flustraminol B 的首次对映选择性合成已经完成。
The organocatalytic enantioselective decarboxylative addition of malonic acids half thioesters to isatins using a squaramide catalyst afforded the products with high enantioselectivity. These products are key intermediates in the synthesis of 3-substituted 3-hydroxy-2-oxindole derivatives. The first enantioselective synthesis of (-)-flustraminol B has been accomplished.