Template-Directed Synthesis of Porous and Protective Core-Shell Bionanoparticles
Template-Directed Synthesis of Porous and Protective Core-Shell Bionanoparticles
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DOI：
10.1002/anie.201604879
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发表时间：
2016-08-26
影响因子：
16.6
通讯作者：
Gassensmith, Jeremiah J.
中科院分区：
文献类型：
--
作者：
Li, Shaobo;Dharmarwardana, Madushani;Gassensmith, Jeremiah J.
金属有机骨架（MOFs）是具有可调孔结构和功能的有前途的高表面积配位聚合物;然而，对所制备的MOFs缺乏良好的尺寸和形态控制一直是其应用中的问题。在这里，我们展示了如何一个强大的蛋白质模板，烟草花叶病毒（TMV），可以用来调节制造的MOF材料的大小和形状。我们能够获得具有良好均匀性的离散棒状TMV@MOF核-壳杂化物，并且它们的直径可以通过调节合成条件来调节，这也可以显著影响核-壳复合物的稳定性。更有趣的是，MOF壳下的病毒颗粒可以使用标准的生物缀合反应进行化学修饰，显示MOF壳内的质量传输。
Metal-organic frameworks (MOFs) are promising high surface area coordination polymers with tunable pore structures and functionality; however, a lack of good size and morphological control over the as-prepared MOFs has persisted as an issue in their application. Herein, we show how a robust protein template, tobacco mosaic virus (TMV), can be used to regulate the size and shape of as-fabricated MOF materials. We were able to obtain discrete rod-shaped TMV@MOF core-shell hybrids with good uniformity, and their diameters could be tuned by adjusting the synthetic conditions, which can also significantly impact the stability of the core-shell composite. More interestingly, the virus particle underneath the MOF shell can be chemically modified using a standard bioconjugation reaction, showing mass transportation within the MOF shell.