The inheritance of sinking‐pre‐beta lipo‐protein and its relation to the Lp(a) antigen *
The inheritance of sinking‐pre‐beta lipo‐protein and its relation to the Lp(a) antigen *
复制标题
下沉前β脂蛋白的遗传及其与Lp(a)抗原的关系*
作者：
D. Hewitt;J. Milner;A. R. Owen;W. Breckenridge;G. Maguire;G. J. Jones;J. Little
我们研究了血浆沉降前β脂蛋白（spβ）的遗传学，通过Breckenridge和Maguire的方法测定，使用几种方法：（i）人群研究，（ii）双胞胎研究和（iii）使用家庭数据。此外，通过使用分离样本，我们测定的spβ水平与Kåre贝格博士在奥斯陆进行的Lp（a）分型相关。虽然spβ水平是一个连续的性状，但结果清楚地表明它在相当程度上受由等位基因Lpa和Lp组成的主要常染色体基因对的控制，该基因对主要控制Lp（a）抗原的产生，其中Lpa为显性。在我们的数据中，LpLp和Lpa Lp基因型之间的界限似乎落在spβ 2和3mg %水平之间，而Lpa Lp和Lpa Lpa之间的界限在15mg %区域。这些界限，这是推断从两个分型和人口统计数据，得到了很好的证实，从家庭数据。看来，约88%的物种水平的变化是直接归因于分离的Lpa和Lp。根据双生子研究和其它资料，我们认为spβ的剩余观测变异几乎完全归因于测定的分析误差和多基因效应，环境的影响可以忽略不计。遗传率接近100%。
We have investigated the genetics of plasma sinking‐pre‐beta lipoprotein (spβ) as determined by the method of Breckenridge and Maguire, using several approaches: (i) a population study, (ii) a twin study and (iii) the use of family data. In addition, by the use of split samples, the spβ level as determined by us was correlated with Lp(a) typing carried out in Oslo by Dr. Kåre Berg. Although the spβ level is a continuous character, the results clearly showed it to be to a considerable extent under the control of the major autosomal gene pair constituted by the alleles Lpa and Lp, which mainly control the production of the Lp(a) antigen, Lpa being dominant. In our data the boundary between the LpLp and Lpa Lp genotypes appeared to fall between the spβ 2 and 3 mg% levels, while that between Lpa Lp and Lpa Lpa was in the 15 mg% region. These boundaries, which were inferred from both typing and population statistics, received good confirmation from the family data. It appears that some 88% of the variation in spp level is directly ascribed to segregation of Lpa and Lp. On the basis of the twin study and other data, we conclude that the residual observed variation in spβ is almost entirely ascribed to analytical error of determination and polygenic effects, the influence of environment being negligible. The heritability is close to 100%.