Statistical mechanics of protein sequences.
Statistical mechanics of protein sequences.
复制标题
蛋白质序列的统计力学。
DOI：
10.1103/physreve.60.4652
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Dewey,TG
中科院分区：
文献类型：
--
作者：
Dewey,TG
A statistical mechanical treatment of biological macromolecules is presented that includes the sequence information as an internal coordinate. Using a path integral representation, the canonical partition function can be represented as a product of a polymer configurational path integral and a sequence walk path integral. In most biological instances, the sequence composition influences the potential energy of intersubunit interaction. Consequently, the two path integrals are not separable, but rather “interact” via a sequence-dependent configurational potential. In proteins and RNA, the sequence walk occurs in dimensions greater than three and, therefore, will be an ideal “polymer.” The Markovian nature of this walk can be exploited to show that all the structural information is contained in the sequence. This latter effect is a result of the dimensionality of the sequence walk and is not necessarily a result of biological optimization of the system.
