3D printed auxetic nasopharyngeal swabs for COVID-19 sample collection.
3D printed auxetic nasopharyngeal swabs for COVID-19 sample collection.
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DOI：
10.1016/j.jmbbm.2020.104175
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发表时间：
2021-03
影响因子：
3.9
通讯作者：
Robinson J
中科院分区：
文献类型：
--
作者：
Arjunan A;Zahid S;Baroutaji A;Robinson J
新冠肺炎疫情导致全球范围内样本采集所需的鼻咽拭子短缺。尽管由于供应链中断，短缺变得日益严重，但作为取消限制的先决条件和为第二波测试做准备，对测试的需求有所增加。这场危机的潜在解决方案之一是开发3D打印鼻咽拭子，其行为方式与传统棉签相似。然而，以数字方式构思和制造棉签的机会允许改进设计，潜在地可以减少患者的痛苦和不适。这项研究报告了在开发可在轴向阻力下收缩的鼻咽部伸展棉签方面取得的进展。这使得棉签可以在显著减少对周围组织的压力的情况下通过鼻腔。这是通过在生物兼容材料中系统地构思负泊松比()结构来实现的。使用有限元(FE)和代理建模技术来确定在安全应力()下允许最大负应变()的最佳棉签形状。研究了不同几何参数对棉签性能的影响和交互作用。这项研究为开发可3D打印的功能性鼻咽拭子提供了一种新的观点，以减少患者的不适。该方法可以进一步利用来解决生物医学设备和再分布制造中的各种挑战。
The COVID-19 pandemic has resulted in worldwide shortages of nasopharyngeal swabs required for sample collection. While the shortages are becoming acute due to supply chain disruptions, the demand for testing has increased both as a prerequisite to lifting restrictions and in preparation for the second wave. One of the potential solutions to this crisis is the development of 3D printed nasopharyngeal swabs that behave like traditional swabs. However, the opportunity to digitally conceive and fabricate swabs allows for design improvements that can potentially reduce patient pain and discomfort. The study reports the progress that has been made on the development of auxetic nasopharyngeal swabs that can shrink under axial resistance. This allows the swab to navigate through the nasal cavity with significantly less stress on the surrounding tissues. This is achieved through systematically conceived negative Poisson's ratio () structures in a biocompatible material. Finite element (FE) and surrogate modelling techniques were employed to identify the most optimal swab shape that allows for the highest negative strain () under safe stress (). The influence and interaction effects of the geometrical parameters on the swab's performance were also characterised. The research demonstrates a new viewpoint for the development of functional nasopharyngeal swabs that can be 3D printed to reduce patient discomfort. The methodology can be further exploited to address various challenges in biomedical devices and redistributed manufacturing.
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影响因子：
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作者：
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