Oral contraceptives decrease the prevalence of ovarian cancer in the hen.
Oral contraceptives decrease the prevalence of ovarian cancer in the hen.
复制标题
口服避孕药可降低母鸡卵巢癌的患病率。
DOI：
10.1158/1940-6207.capr-11-0344
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Johnson,PatriciaA
中科院分区：
文献类型：
--
作者：
Treviño,LindseyS;Buckles,ElizabethL;Johnson,PatriciaA
卵巢癌是美国女性生殖系统癌症死亡的主要原因。如此高的死亡率是由于缺乏早期检测方法和晚期疾病治疗无效造成的。在开发出更有效的筛查方法和疗法之前，化学预防策略是有必要的。母鸡卵巢癌的自发患病率很高，已被用作研究卵巢癌化学预防的模型。在这项研究中，我们使用母鸡来确定单独使用孕激素、单独使用雌激素或联合使用孕激素和雌激素（如口服避孕药中的成分）对卵巢癌患病率的影响。我们发现单独使用孕激素或与雌激素联合治疗可降低卵巢癌的患病率。单独使用孕激素治疗组的风险显着降低了 91%（风险比 = 0.0909；95% CI：0.0117–0.704），孕激素加雌激素治疗组的风险显着降低了 81%（风险比 = 0.1916；95% CI = 0.043–0.864）。与对照组相比，这些处理组的产蛋量也显着减少。我们发现孕激素，无论是单独使用还是与雌激素联合使用，对卵巢细胞凋亡或增殖都没有影响，表明这可能不是孕激素对母鸡产生保护作用的机制。我们的研究结果支持使用口服避孕药来预防卵巢癌，并表明排卵与母鸡患卵巢癌的风险有关，而激素等其他因素很可能会改变这种风险。 5(2)； 343–9。 ©2011 AACR。
Ovarian cancer is the leading cause of reproductive cancer death in U.S. women. This high mortality rate is due to the lack of early detection methods and ineffectiveness of therapy for advanced disease. Until more effective screening methods and therapies are developed, chemoprevention strategies are warranted. The hen has a high spontaneous prevalence of ovarian cancer and has been used as a model for studying ovarian cancer chemoprevention. In this study, we used the hen to determine the effect of progestin alone, estrogen alone, or progestin and estrogen in combination (as found in oral contraceptives) on ovarian cancer prevalence. We found that treatment with progestin alone and in combination with estrogen decreased the prevalence of ovarian cancer. A significant risk reduction of 91% was observed in the group treated with progestin alone (risk ratio = 0.0909; 95% CI: 0.0117–0.704) and an 81% reduction was observed in the group treated with progestin plus estrogen (risk ratio = 0.1916; 95% CI = 0.043–0.864). Egg production was also significantly reduced in these treatment groups compared with control. We found no effect of progestin, either alone or in combination with estrogen, on apoptosis or proliferation in the ovary, indicating that this is not the likely mechanism responsible for the protective effect of progestin in the hen. Our results support the use of oral contraceptives to prevent ovarian cancer and suggest that ovulation is related to the risk of ovarian cancer in hens and that other factors, such as hormones, more than likely modify this risk.Cancer Prev Res; 5(2); 343–9. ©2011 AACR.