Novel MRI Technique Enables Non-Invasive Measurement of Atrial Wall Thickness.
Novel MRI Technique Enables Non-Invasive Measurement of Atrial Wall Thickness.
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DOI：
10.1109/tmi.2017.2671839
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发表时间：
2017-08
影响因子：
10.6
通讯作者：
Aslanidi OV
中科院分区：
文献类型：
--
作者：
Varela M;Morgan R;Theron A;Dillon-Murphy D;Chubb H;Whitaker J;Henningsson M;Aljabar P;Schaeffter T;Kolbitsch C;Aslanidi OV
了解心房壁厚度（AWT）有可能为患者分层和房性心律失常干预计划提供重要信息。迄今为止，关于AWT的信息仅在死后或对比度差的CT研究中获得，提供了有限的覆盖范围和高度可变的AWT估计值。我们提出了一种新的无造影剂的MRI序列成像AWT，并使用它来创建个性化的AWT地图和双心房图谱。一种新的黑血相敏反转恢复协议被用来成像10名志愿者，作为概念证明，2名房颤患者。使用最近邻平均法手动分割两个心房以创建受试者特异性AWT图。然后将这些非线性配准以生成AWT图谱。左心房和右心房的房壁厚度分别为2.4 ± 0.7和2.7 ± 0.7 mm，与尸检和CT数据（如可用）一致。1例无器质性心脏病患者左心房AWT为2.6 ± 0.7 mm，与志愿者相似。在结构性心脏病患者的AWT增加到3.1 ± 1.3 mm。我们成功地设计了一个MRI协议，以非侵入性测量AWT，并创建了第一个全心房AWT图谱。该图谱可用作研究心房病理引起的厚度变化的参考。该协议可用于在临床环境中获取个性化AWT标测图，并辅助治疗房性心律失常。
Knowledge of atrial wall thickness (AWT) has the potential to provide important information for patient stratification and the planning of interventions in atrial arrhythmias. To date, information about AWT has only been acquired in post-mortem or poor-contrast CT studies, providing limited coverage and highly variable estimates of AWT. We present a novel contrast agent-free MRI sequence for imaging AWT and use it to create personalized AWT maps and a biatrial atlas. A novel black-blood phase-sensitive inversion recovery protocol was used to image 10 volunteers and, as proof of concept, 2 atrial fibrillation patients. Both atria were manually segmented to create subject-specific AWT maps using an average of nearest neighbors approach. These were then registered non-linearly to generate an AWT atlas. Atrial wall thickness was 2.4 ± 0.7 and 2.7 ± 0.7 mm in the left and right atria, respectively, in good agreement with post-mortem and CT data, where available. AWT was 2.6 ± 0.7 mm in the left atrium of a patient without structural heart disease, similar to that of volunteers. In a patient with structural heart disease the AWT was increased to 3.1 ± 1.3 mm. We successfully designed an MRI protocol to non-invasively measure AWT and create the first whole-atria AWT atlas. The atlas can be used as a reference to study alterations in thickness caused by atrial pathology. The protocol can be used to acquire personalized AWT maps in a clinical setting and assist in the treatment of atrial arrhythmias.