REDUCTION OF METASTASIS IN A MURINE MAMMARY-TUMOR MODEL BY HEPARIN AND POLYINOSINIC-POLYCYTIDYLIC ACID
REDUCTION OF METASTASIS IN A MURINE MAMMARY-TUMOR MODEL BY HEPARIN AND POLYINOSINIC-POLYCYTIDYLIC ACID
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DOI：
10.1007/bf00117789
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发表时间：
1990-03-01
影响因子：
4
通讯作者：
JEFFERY, RE
中科院分区：
文献类型：
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作者：
LEE, AE;ROGERS, LA;JEFFERY, RE
一个小鼠乳腺肿瘤模型被用来测试肝素和干扰素诱导剂poly I:C联合使用对s.c.原发肿瘤自发转移和静脉注射肿瘤细胞后实验性转移的影响。这种治疗对原发肿瘤的生长没有影响，但这些肿瘤引起的肺转移减少了。肿瘤细胞静脉注射后，肺内菌落数量明显减少，存活时间延长。短期治疗并不能阻止外渗的休眠肿瘤细胞的生长，尽管治疗8至12周的小鼠存活了至少6个月，没有任何肺部菌落的迹象。几种机制可能有助于这种治疗的总体效果；肺部菌落有丝分裂指数的降低（在poly I:C治疗的小鼠中观察到）和NK细胞的降低似乎对poly I:C的有效性很重要，因为与抗亚洲草GM1血清同时治疗可以消除实验转移的减少。
A murine mammary tumour model has been used to test the efficacy of a combination of heparin and the interferon inducer, poly I:C on spontaneous metastasis from a s.c. primary tumour and on experimental metastasis following i.v. injection of tumour cells. This treatment has no effect on the growth of primary tumours, but lung metastases arising form these tumours were reduced. When tumour cells were injected i.v. the number of lung colonies was significantly reduced and survival time extended. Short-term treatment did not prevent the subsequent growth of extravasated, but dormant tumour cells, although mice treated for 8 to 12 weeks survived at least 6 months wihtout any sign of lung colonies. Several mechanisms may contribute to the overall effect of this treatment; a reduction in the mitotic indices of lung colonies (observed in poly I:C treated mice) and also NK cells appeared to be important for the effectiveness of poly I:C since the reduction in experimental metastasis was abrogated by concomitant treatment with anti-asialo GM1 serum.