A zone of frontonasal ectoderm regulates patterning and growth in the face
A zone of frontonasal ectoderm regulates patterning and growth in the face
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DOI：
10.1242/dev.00397
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发表时间：
2003-05-01
期刊：
影响因子：
4.6
通讯作者：
Helms, JA
中科院分区：
文献类型：
--
作者：
Hu, D;Marcucio, RS;Helms, JA
一组基本的模式基因可以定义颅面区域的整体组织。我们的目标之一是确定这些基本的模式基因，并了解它们如何调节额鼻突的生长，从而产生中面部和上面部。我们确定了一个分子边界的额鼻突外胚层，定义成纤维细胞生长因子8和Sonic刺猬，这预示着最初的网站额鼻突生长的并列结构域。命运图证实，这一边界区域后来划定了上喙的背腹轴。异位移植的外胚层边界区域激活了一系列分子事件，重新编程的神经嵴衍生的间充质的发育命运，从而导致重复的上部和下部喙结构。我们讨论这些数据的背景下，边界/形态模型的图案，并在最近的争议，神经嵴prepatterning与神经嵴可塑性。
A fundamental set of patterning genes may define the global organization of the craniofacial region. One of our goals has been to identify these basic patterning genes and understand how they regulate outgrowth of the frontonasal process, which gives rise to the mid and upper face. We identified a molecular boundary in the frontonasal process ectoderm, defined by the juxtaposed domains of Fibroblast growth factor 8 and Sonic hedgehog, which presaged the initial site of frontonasal process outgrowth. Fate maps confirmed that this boundary region later demarcated the dorsoventral axis of the upper beak. Ectopic transplantation of the ectodermal boundary region activated a cascade of molecular events that reprogrammed the developmental fate of neural crest-derived mesenchyme, which resulted in duplications of upper and lower beak structures. We discuss these data in the context of boundary/morphogen models of patterning, and in view of the recent controversy regarding neural crest prepatterning versus neural crest plasticity.