On the potential role of exosomes in the COVID-19 reinfection/reactivation opportunity
On the potential role of exosomes in the COVID-19 reinfection/reactivation opportunity
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DOI：
10.1080/07391102.2020.1790426
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发表时间：
2020-07-08
影响因子：
4.4
通讯作者：
Uversky, Vladimir N.
中科院分区：
文献类型：
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作者：
Elrashdy, Fatma;Aljaddawi, Abdullah A.;Uversky, Vladimir N.
我们认为新冠肺炎复发的潜在机制之一可能是与携带SARS-CoV-2的外切体和其他细胞外小泡的释放有关的细胞转运途径。这种“特洛伊木马”策略可能是出院后7-14天新冠肺炎康复患者体内病毒核糖核酸重新出现的可能解释，这表明病毒物质在这段“沉默”时间段内隐藏在这些外体或细胞外小泡中，然后开始再次传播。拉马斯瓦米·H·萨尔马沟通
We propose here that one of the potential mechanisms for the relapse of the COVID-19 infection could be a cellular transport pathway associated with the release of the SARS-CoV-2-loaded exosomes and other extracellular vesicles. It is possible that this "Trojan horse" strategy represents possible explanation for the re-appearance of the viral RNA in the recovered COVID-19 patients 7-14 day post discharge, suggesting that viral material was hidden within such exosomes or extracellular vesicles during this "silence" time period and then started to re-spread again. Communicated by Ramaswamy H. Sarma