Magnetic resonance elastography of the brain
Magnetic resonance elastography of the brain
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DOI：
10.1016/j.neuroimage.2007.08.030
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发表时间：
2008-01-01
期刊：
影响因子：
5.7
通讯作者：
Ehman, Richard L.
中科院分区：
文献类型：
--
作者：
Kruse, Scott A.;Rose, Gregory H.;Ehman, Richard L.
本研究的目的是使用磁共振弹性成像(MRE)获得标准化数据，(A)获得活体人脑组织剪切模数的估计值，以及(B)评估健康成年志愿者脑组织剪切模数的可能年龄相关性。对模拟组织的明胶模型和25名健康成人志愿者进行了磁共振弹性成像研究。使用时空滤波器和局部频率估计算法对数据进行分析。采用配对t检验进行统计分析。脑白质的平均剪切硬度为13.6kPa(95%CI为12.3~14.8kPa)，灰质的剪切刚度较低，为5.22kPa(95%CI为4.76~5.66kPa)。差异有统计学意义(p<；0.0001)。(C)2007年，爱思唯尔公司出版。
The purpose of this study was to obtain normative data using magnetic resonance elastography (MRE) (a) to obtain estimates of the shear modulus of human cerebral tissue in vivo and (b) to assess a possible age dependence of the shear modulus of cerebral tissue in healthy adult volunteers. MR elastography studies were performed on tissue-simulating gelatin phantoms and 25 healthy adult volunteers. The data were analyzed using spatiotemporal filters and a local frequency estimating algorithm. Statistical analysis was performed using a paired t-test. The mean shear stiffness of cerebral white matter was 13.6 kPa (95% Cl 12.3 to 14.8 kPa); while that of gray matter was lower at 5.22 kPa (95% Cl 4.76 to 5.66 kPa). The difference was statistically significant (p < 0.0001). (C) 2007 Published by Elsevier Inc.