Vitamin D deficiency during pregnancy may impair maternal and fetal outcomes
Vitamin D deficiency during pregnancy may impair maternal and fetal outcomes
复制标题
DOI：
10.1016/j.mehy.2009.07.054
复制
发表时间：
2010-01-01
影响因子：
4.7
通讯作者：
Lapillonne, Alexandre
中科院分区：
文献类型：
--
作者：
Lapillonne, Alexandre
在过去的十年中，新的证据表明，维生素D缺乏可能会增加患多种常见慢性疾病的风险，而这些疾病与钙和骨骼稳态的经典作用不同。维生素D通过维生素D受体发挥作用，可以通过基因组、非基因组或内分泌机制产生广泛的有利生物效应，因此有助于改善人类健康。我们推测，其中一些影响在怀孕期间可能更为严重。本文的重点是回顾有关维生素D与妊娠的经典和非经典作用的数据。怀孕期间维生素D不足可能会增加子痫前期、胰岛素抵抗和妊娠糖尿病的风险。此外，实验数据还预测维生素D充足对胎儿发育，特别是胎儿大脑发育和免疫功能至关重要。因此，怀孕期间缺乏维生素D不仅会损害母体骨骼的保存和胎儿骨骼的形成，而且对胎儿的“印记”也至关重要，胎儿的“印记”可能会在出生后不久以及以后的生活中影响慢性疾病的易感性。2009爱思唯尔有限公司版权所有。
Over the past decade, new evidence has shown that vitamin D deficiency may contribute to the risk of developing a wide range of common chronic diseases that are different from the classic action on calcium and bone homeostasis. Acting through the vitamin D receptor, vitamin D can produce a wide array of favorable biological effects via genomic, non-genomic or intracrine mechanisms and, therefore, contributes to the improvement of human health in humans. We hypothesize that some of these effects may be even more critical during pregnancy. The focus of this paper is to review the data on the classic and non-classic actions of vitamin D with regards to pregnancy. It appears that vitamin D insufficiency during pregnancy is potentially associated with increased risk of preeclampsia, insulin resistance and gestational diabetes mellitus. Furthermore, experimental data also anticipate that vitamin D sufficiency is critical for fetal development, and especially for fetal brain development and immunological functions. Vitamin D deficiency during pregnancy may, therefore, not only impair maternal skeletal preservation and fetal skeletal formation but also be vital to the fetal "imprinting" that may affect chronic disease susceptibility soon after birth as well as later in life. (C) 2009 Elsevier Ltd. All rights reserved.