Abnormal autonomic and associated brain activities during rest in autism spectrum disorder
Abnormal autonomic and associated brain activities during rest in autism spectrum disorder
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自闭症谱系障碍患者休息时自主神经和相关大脑活动异常
DOI：
10.1093/brain/awt294
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发表时间：
2014-01-01
期刊：
影响因子：
14.5
通讯作者：
Fan, Jin
中科院分区：
文献类型：
--
作者：
Eilam-Stock, Tehila;Xu, Pengfei;Fan, Jin
自闭症谱系障碍与社会和情感缺陷有关，其病因尚不清楚。越来越多的共识是，自主神经系统通过提供主观状态所必需的生理信号，在情绪过程中发挥着关键作用。我们假设自主神经处理的改变与自闭症谱系障碍的社会情感缺陷有关。在这里，我们调查了非特异性皮肤电导反应，交感神经活动的客观指标，和大脑波动在休息期间的高功能成人自闭症谱系障碍相对于神经正常对照之间的关系。与对照组相比，自闭症谱系障碍患者的皮肤电导反应总体上较少。他们还显示，皮肤电导反应与额叶脑区（包括前扣带皮层和前岛叶皮层）之间的相关性较弱。此外，发现皮肤电导反应对自闭症谱系障碍患者的默认模式网络连接的贡献较小。这些结果表明，自闭症谱系障碍的自主处理发生了改变，这可能与这种情况下的异常社会情绪行为有关。
Autism spectrum disorders are associated with social and emotional deficits, the aetiology of which are not well understood. A growing consensus is that the autonomic nervous system serves a key role in emotional processes, by providing physiological signals essential to subjective states. We hypothesized that altered autonomic processing is related to the socio-emotional deficits in autism spectrum disorders. Here, we investigated the relationship between non-specific skin conductance response, an objective index of sympathetic neural activity, and brain fluctuations during rest in high-functioning adults with autism spectrum disorder relative to neurotypical controls. Compared with control participants, individuals with autism spectrum disorder showed less skin conductance responses overall. They also showed weaker correlations between skin conductance responses and frontal brain regions, including the anterior cingulate and anterior insular cortices. Additionally, skin conductance responses were found to have less contribution to default mode network connectivity in individuals with autism spectrum disorders relative to controls. These results suggest that autonomic processing is altered in autism spectrum disorders, which may be related to the abnormal socio-emotional behaviours that characterize this condition.