A Review on Recent Advancement on Age-Related Hearing Loss: The Applications of Nanotechnology, Drug Pharmacology, and Biotechnology.
A Review on Recent Advancement on Age-Related Hearing Loss: The Applications of Nanotechnology, Drug Pharmacology, and Biotechnology.
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DOI：
10.3390/pharmaceutics13071041
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发表时间：
2021-07-08
期刊：
影响因子：
5.4
通讯作者：
Al-Salami H
中科院分区：
文献类型：
--
作者：
Chester J;Johnston E;Walker D;Jones M;Ionescu CM;Wagle SR;Kovacevic B;Brown D;Mikov M;Mooranian A;Al-Salami H
衰老被认为是导致心血管疾病、阿尔茨海默病和听力丧失等许多疾病的一个因素。与年龄相关的听力损失，也被称为老年性耳聋，是世界上最常见的感觉障碍之一，影响着五分之一的50岁以上的人，而且这一患病率每年都在增长。老年性耳聋与有害健康结果（包括社会孤立和心理健康）之间存在关联。除了助听器，它在很大程度上仍然无法治疗，而且在临床环境中没有全球公认的预防策略。因此，本文旨在基于胆汁酸生物纳米技术的最新进展，探讨老年性痴呆的病理生理学和潜在的治疗方法。使用以下关键词进行了全面的在线搜索：老年性耳聋，药物，听力损失，胆汁酸，纳米技术，并认为直接相关的150多篇出版物。越来越多的证据表明，氧化应激和慢性炎症参与细胞损伤和凋亡，这与毛细胞的损失、血管纹的损伤和炎症以及神经元信号的丢失和凋亡有关。新的强大而有效的治疗方法需要将药物输送到耳蜗的各个层。基于胆汁酸的纳米技术因其增强渗透能力和在治疗老年性痴呆方面的众多应用潜力而受到广泛关注。
Aging is considered a contributing factor to many diseases such as cardiovascular disease, Alzheimer’s disease, and hearing loss. Age-related hearing loss, also termed presbycusis, is one of the most common sensory impairments worldwide, affecting one in five people over 50 years of age, and this prevalence is growing annually. Associations have emerged between presbycusis and detrimental health outcomes, including social isolation and mental health. It remains largely untreatable apart from hearing aids, and with no globally established prevention strategies in the clinical setting. Hence, this review aims to explore the pathophysiology of presbycusis and potential therapies, based on a recent advancement in bile acid-based bio-nanotechnologies. A comprehensive online search was carried out using the following keywords: presbycusis, drugs, hearing loss, bile acids, nanotechnology, and more than 150 publications were considered directly relevant. Evidence of the multifaceted oxidative stress and chronic inflammation involvement in cellular damage and apoptosis that is associated with a loss of hair cells, damaged and inflamed stria vascularis, and neuronal signalling loss and apoptosis continues to emerge. New robust and effective therapies require drug delivery deeper into the various layers of the cochlea. Bile acid-based nanotechnology has gained wide interest in its permeation-enhancing ability and potential for numerous applications in treating presbycusis.
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影响因子：
3.6
作者：
Ciorba A;Bianchini C;Pelucchi S;Pastore A
通讯作者：
Pastore A
DOI：
10.1056/nejmra1616601
发表时间：
2017-12-21
期刊：
The New England journal of medicine
影响因子：
--
作者：
Cunningham LL;Tucci DL
通讯作者：
Tucci DL
通过了解纳米颗粒特性和细胞穿透肽对耳蜗药物输送的影响，设计基于 PLGA 纳米的系统
影响因子：
5.8
作者：
Cai, Hui;Liang, Zhongping;Chen, Gang
通讯作者：
Chen, Gang
影响因子：
--
作者：
Chiang, John Y L;Ferrell, Jessica M
通讯作者：
Ferrell, Jessica M
影响因子：
--
作者：
Asiri YA
通讯作者：
Asiri YA