Acute Nicotinamide Deficiency in the Pig Induced by 6-aminonicotinamide
Acute Nicotinamide Deficiency in the Pig Induced by 6-aminonicotinamide
复制标题
6-氨基烟酰胺所致猪急性烟酰胺缺乏症
DOI：
10.1177/030098588001700610
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发表时间：
1980
影响因子：
2.4
通讯作者：
W. Blakemore
中科院分区：
文献类型：
--
作者：
B. O'Sullivan;W. Blakemore
Pigs given intraperitoneal injections of 6-aminonicotinamide developed a syndrome similar to a natural disease found in Queensland. Focal lesions, involving mainly destruction of glial cells, developed in the intermediate grey matter of the cervical and lumbar enlargement of the spinal cord. There was widespread vacuolation of spinal cord white matter. The glial cell loss was repaired. We suggest that natural acute nicotinamide deficiency can occur if a threshold dose of an antimetabolite of nicotinamide is absorbed over a short period of time.
