RELATIONSHIP BETWEEN ALTERNATE ROUTES OF TRYPTOPHAN METABOLISM FOLLOWING ADMINISTRATION OF TRYPTOPHAN PEROXIDASE INDUCERS OR STRESSORS 1
RELATIONSHIP BETWEEN ALTERNATE ROUTES OF TRYPTOPHAN METABOLISM FOLLOWING ADMINISTRATION OF TRYPTOPHAN PEROXIDASE INDUCERS OR STRESSORS 1
复制标题
给予色氨酸过氧化物酶诱导剂或应激剂后色氨酸代谢的替代途径之间的关系 1
DOI：
10.1111/j.1471-4159.1971.tb11989.x
复制
发表时间：
1971
影响因子：
4.7
通讯作者：
Edward Geller
中科院分区：
文献类型：
--
作者：
Arthur Yuwiler;Lennart Wetterberg;Edward Geller
摘要：糖皮质激素可提高大鼠肝脏色氨酸过氧化物酶（EC 1.11.1.4）的活性，降低脑血清素。葡萄糖预处理降低了这两种效果。肾上腺素化大鼠服用烯丙基异丙酰胺可增加脑干色氨酸过氧化物酶活性和脑血清素水平，但对脑干色氨酸羟化酶（EC 1.99.1.4）活性无影响。色氨酸过氧化物酶的活性随着剖腹手术的急性应激和禁食72小时的慢性应激而增加。两种压力源都没有明显影响大脑血清素水平。这些结果反驳了色氨酸过氧化物酶活性通过将色氨酸从单胺的生物合成中转移而直接影响脑5 -羟色胺合成的说法。
Abstract— Administration of glucocorticoids to rats increased the activity of hepatic tryptophan peroxidase (EC 1.11.1.4) and lowered brain serotonin. Pretreatment with glucose diminished both of these effects. Administration of allylisopropylacetamide to adrenalecto‐mized rats increased both the activity of tryptophan peroxidase and the level of brain serotonin but had no effect on tryptophan hydroxylase (EC 1.99.1.4) activity in the brain stem. The activity of tryptophan peroxidase was increased by the acute stress of laparotomy and by the chronic stress of a 72‐h fast. Neither stressor affected brain serotonin levels appreciably. These results argue against the proposal that the activity of tryptophan peroxidase activity directly affects synthesis of brain serotonin by diverting tryptophan from the biosynthesis of this monoamine.