Insulin-like growth factor physiology and cancer risk
Insulin-like growth factor physiology and cancer risk
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DOI：
10.1016/s0959-8049(00)00102-7
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发表时间：
2000-06-01
影响因子：
8.4
通讯作者：
Pollak, M
中科院分区：
文献类型：
--
作者：
Pollak, M
在过去的几年中，实验室调查和人群研究都提供了强有力的间接证据，证明胰岛素样生长因子（IGF）生理学会影响癌症风险。与罕见但与极高风险相关的种系突变的影响相比，IGF 生理学的个体间变异对风险的影响似乎不大，但影响相对较高比例的人群。尽管这项研究还很年轻，但人们已经注意到它可能与风险的临床评估和/或新的预防策略和中间终点的确定相关的可能性。这篇综述总结了该领域的关键结果，并提供了关于 IGF 生理学影响常见上皮癌（包括乳腺癌）风险的机制的假设。前列腺、肺和结肠。 (C) 2000 年由爱思唯尔科学有限公司出版。保留所有权利。
In the past few years, both laboratory investigations and population studies have provided strong circumstantial evidence that insulin-like growth factor (IGF) physiology influences cancer risk. In contrast to the influence of germ line mutations that are rare but are associated with very high risks, the impact of inter-individual variability in IGF physiology on risk appears to be modest but to effect a relatively high percentage of the population. Although this held of investigation is young, attention is already being given to the possibility that it may be relevant to clinical assessment of risk and/or to the identification of novel prevention strategies and intermediate endpoints. This review summarises key results in this field and provides a hypothesis concerning the mechanism by which IGF physiology influences risk of common epithelial cancers including those of breast. prostate, lung and colon. (C) 2000 Published by Elsevier Science Ltd. All rights reserved.