Ultrastable Near-Infrared Nonlinear Organic Chromophore Nanoparticles with Intramolecular Charge Transfer for Dually Photoinduced Tumor Ablation.
Ultrastable Near-Infrared Nonlinear Organic Chromophore Nanoparticles with Intramolecular Charge Transfer for Dually Photoinduced Tumor Ablation.
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具有分子内电荷转移的超稳定近红外非线性有机发色团纳米粒子，用于双重光诱导肿瘤消融
DOI：
10.1002/adhm.202001042
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发表时间：
2020
影响因子：
10
通讯作者：
Guo Zhengqing
中科院分区：
文献类型：
--
作者：
Zhang Yi;Shi Mengke;Yan Zhangren;Zhang Shao;Wang Mengya;Xu Han;Li Hongyu;Ying Yuchen;Qiu Shihong;Liu Jialei;Yang Hong;Chen Huabing;He Hui;Guo Zhengqing
有机光敏剂（PS）的近红外（NIR）光响应纳米颗粒（NP）作为精确光诱导癌症治疗的光治疗剂具有很大的前景。然而，具有非凡的光转换能力的高度光稳定的PS纳米颗粒是迫切需要的，以充分实现有效的光疗。在这里，NIR非线性有机发色团纳米颗粒（NOC-NPs）被示出为用于双重协作光疗的单组分PS。在785 nm照射下，激发的NOC-NPs通过固有的分子内电荷转移（ICT）通道产生丰富的单线态氧和局部热疗，为肿瘤消融提供协同的光动力学治疗（PDT）和光热治疗（PTT）。此外，NOC-NP表现出显著的光稳定性，增强的细胞摄取，有效的细胞质易位，以及优选的肿瘤积累，进一步确保有利的体内单线态氧产生和用于光诱导肿瘤消融的热疗。因此，NOC-NPs可能代表了用于协同光诱导癌症治疗的新型高性能PS，为开发用于临床转化的强效PS提供了新的见解。
Near‐infrared (NIR) light‐responsive nanoparticles (NPs) of organic photosensitizers (PS) hold great promise as phototherapeutic agents for precision photoinduced cancer therapy. However, highly photostable PS nanoparticles with extraordinary photoconversion capacities are urgently desired to fully realize potent phototherapy. Here, NIR nonlinear organic chromophore nanoparticles (NOC‐NPs) are shown as single‐component PS for dually cooperative phototherapy. Upon 785 nm irradiation, excited NOC‐NPs pass through intrinsic intramolecular charge transfer (ICT) channel to generate both abundant singlet oxygen and local hyperthermia, affording synergistic photodynamic therapy (PDT) and photothermal therapy (PTT) for tumor ablation. Furthermore, NOC‐NPs exhibit dramatic photostability, enhanced cellular uptake, effective cytoplasmic translocation, as well as preferable tumor accumulation, further ensuring favorable in vivo singlet oxygen generation and hyperthermia for photoinduced tumor ablation. Thus, NOC‐NPs may represent novel high‐performance PS for synergistic photoinduced cancer therapy, providing new insights into the development of potent PS for clinical translation.