The Agonist-antagonist Myoneural Interface.
The Agonist-antagonist Myoneural Interface.
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DOI：
10.1097/bto.0000000000000552
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Carty MJ
中科院分区：
文献类型：
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作者：
Herr H;Carty MJ
长期以来，科学家和技术人员一直在寻求推进直接连接到外周神经系统的假肢，使截肢者能够自愿控制移动，驱动和驱动假肢的合成致动器，以及体验来自假肢的自然传入感觉。最近，开发了激动剂-拮抗剂肌神经接口（AMI），这是一种机械神经传导结构和神经接口系统，旨在为截肢患者提供改善的肌肉-肌腱本体感觉和神经假体控制。在本文中，我们提供了一个AMI的概述，包括其概念框架和临床前科学，其建设的外科技术，和临床疗效相关的疼痛缓解，幻肢运动范围，肌束动力学，中枢脑本体感觉运动的保护，和假肢的可控性。在这个广泛的概述之后，我们最后讨论了AMI的当前局限性和这些挑战的潜在解决方案。
Scientist and technologist have long sought to advance limb prostheses that connect directly to the peripheral nervous system, enabling a person with amputation to volitionally control synthetic actuators that move, stiffen and power the prosthesis, as well as to experience natural afferent sensations from the prosthesis. Recently, the agonist-antagonist myoneural interface (AMI) was developed, a mechanoneural transduction architecture and neural interface system designed to provide persons with amputation improved muscle-tendon proprioception and neuroprosthetic control. In this paper, we provide an overview of the AMI, including its conceptual framing and preclinical science, surgical techniques for its construction, and clinical efficacy related to pain mitigation, phantom limb range of motion, fascicle dynamics, central brain proprioceptive sensorimotor preservation, and prosthetic controllability. Following this broad overview, we end with a discussion of current limitations of the AMI and potential resolutions to such challenges.