A comparative study of protein kinase C-like immunoreactive cells in the retina
A comparative study of protein kinase C-like immunoreactive cells in the retina
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DOI：
10.1159/000047217
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发表时间：
2000-12-01
影响因子：
1.7
通讯作者：
Lara, JM
中科院分区：
文献类型：
--
作者：
Caminos, E;Velasco, A;Lara, JM
本研究对五种不同脊椎动物（鸡、鲱鱼、斑马鱼、金鱼和大鼠）视网膜中的蛋白激酶c样免疫反应（PKC-L-ir）双极细胞进行了形态学和定量分析。鱼视网膜PKC-L-ir双极细胞轴突末梢的形态与鸡和大鼠视网膜有显著差异。鱼的末端粗大，而鸡和老鼠的末端是小的旋钮状的树枝。在鲱鱼和金鱼中，PKC-L-ir双极细胞从内侧（即鲱鱼：平均+/- SD体细胞面积为30.09 +/- 5.98 mum(2)）到外周（即鲱鱼：19.93 +/- 1.73 mum(2)）视网膜区域逐渐减小。这在鸡、大鼠或斑马鱼中没有观察到，在不同的视网膜区域之间有更多的体细胞和轴突末端大小的同质性。除鸡外，细胞密度从中央(如，e。，单位：平均SD 1795.88 +/- 242.35 cells/mm(2))。视网膜：4295.41 +/- 279.23细胞/毫米(2)。本研究提供的数据显示了鸟类、鱼类和哺乳动物PKC-L-ir双极形态和密度的相关差异。此外，这些结构上的差异不仅意味着细胞生理学上的差异，还意味着每个物种视网膜的发育和维护模式的差异。版权所有(C) 2001 S. Karger AG，巴塞尔
The present study is a morphological and quantitative analysis of protein kinase C-like immunoreactive (PKC-L-ir) bipolar cells in the retinas of five different vertebrate species (chicken, tench, zebrafish, goldfish and rat). The morphology of PKC-L-ir bipolar cell axon terminals in fish differs significantly from those of chicken and rat retinas. Fish have bulky terminals whereas chicken and rat have their terminals in the form of small knob-shaped branches. In tench and goldfish, PKC-L-ir bipolar cells gradually decrease in size from the medial (i.e., in tench: mean +/- SD soma area of 30.09 +/- 5.98 mum(2)) to the peripheral (i.e., in tench: 19.93 +/- 1.73 mum(2)) retinal regions. This is not observed in chicken, rat or zebrafish where there is more homogeneity in soma and axon terminal sizes between different retinal regions. Except in chicken, cell density increases from the central (i,e., in tench: mean i SD 1795.88 +/- 242.35 cells/mm(2)) to the peripheral (i,e., in tench: 4295.41 +/- 279.23 cells/mm(2)) retina. This study provides data that show relevant differences in the PKC-L-ir bipolar morphology and density among birds, fish and mammals. Moreover, these structural variations could mean not only differences in the cellular physiology, but also in the patterns of development and maintenance of the retina in each species. Copyright (C) 2001 S. Karger AG, Basel.