Caveolin-1: An Oxidative Stress-Related Target for Cancer Prevention.
Caveolin-1: An Oxidative Stress-Related Target for Cancer Prevention.
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Caveolin-1：氧化应激相关的癌症预防靶标
DOI：
10.1155/2017/7454031
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发表时间：
2017
影响因子：
--
通讯作者：
Wang Z
中科院分区：
文献类型：
--
作者：
Wang S;Wang N;Zheng Y;Zhang J;Zhang F;Wang Z
异常的氧化代谢是癌症的标志之一。活性物质的过度生成可通过诱导基因突变和激活致癌通路来促进癌症发生，因此，抗氧化治疗被视为癌症预防和治疗的一项重要策略。小窝蛋白 - 1（Cav - 1）作为小窝的组成蛋白，近来研究表明其可通过调节氧化应激来介导肿瘤的发生和进展。活性物质能够调节Cav - 1的表达、降解、翻译后修饰以及膜转运，而以Cav - 1为靶点的治疗方法则可以清除活性物质。更重要的是，越来越多的证据表明，多种抗氧化剂可通过调节Cav - 1通路，在癌细胞中发挥抗肿瘤活性，在正常细胞中发挥保护作用。综上所述，这些研究结果表明，Cav - 1可能是一个有前景的与氧化应激相关的癌症抗氧化预防靶点。阐明氧化应激与Cav - 1之间潜在的相互作用机制，有助于增强抗氧化剂对癌症的预防效果，改善癌症患者抗氧化相关治疗的临床疗效，并有助于开发以Cav - 1为靶点的药物。在此，我们总结了Cav - 1和氧化应激在肿瘤发生发展中作用的现有证据，并为利用Cav - 1与氧化应激之间的相互作用模式来设计癌症预防或治疗策略提供新的思路。
Aberrant oxidative metabolism is one of the hallmarks of cancer. Reactive species overproduction could promote carcinogenesis via inducing genetic mutations and activating oncogenic pathways, and thus, antioxidant therapy was considered as an important strategy for cancer prevention and treatment. Caveolin-1 (Cav-1), a constituent protein of caveolae, has been shown to mediate tumorigenesis and progression through oxidative stress modulation recently. Reactive species could modulate the expression, degradation, posttranslational modifications, and membrane trafficking of Cav-1, while Cav-1-targeted treatments could scavenge the reactive species. More importantly, emerging evidences have indicated that multiple antioxidants could exert antitumor activities in cancer cells and protective activities in normal cells by modulating the Cav-1 pathway. Altogether, these findings indicate that Cav-1 may be a promising oxidative stress-related target for cancer antioxidant prevention. Elucidating the underlying interaction mechanisms between oxidative stress and Cav-1 is helpful for enhancing the preventive effects of antioxidants on cancer, for improving clinical outcomes of antioxidant-related therapeutics in cancer patients, and for developing Cav-1 targeted drugs. Herein, we summarize the available evidence of the roles of Cav-1 and oxidative stress in tumorigenesis and development and shed novel light on designing strategies for cancer prevention or treatment by utilizing the interaction mode between Cav-1 and oxidative stress.