Modulation of activity of gustatory neurons in the hamster parabrachial nuclei by electrical stimulation of the ventroposteromedial nucleus of the thalamus.
Modulation of activity of gustatory neurons in the hamster parabrachial nuclei by electrical stimulation of the ventroposteromedial nucleus of the thalamus.
复制标题
通过电刺激丘脑腹后内侧核调节仓鼠臂旁核味觉神经元的活动。
DOI：
10.1152/ajpregu.00802.2007
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Li,Cheng-Shu
中科院分区：
文献类型：
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作者：
Mao,Limin;Cho,YoungK;Li,Cheng-Shu
丘脑腹后内侧核（VPMpc）的细胞旁部分位于味觉臂旁核（PbN）和味觉皮层之间的关键部位，通过丘脑皮质通路传递和处理味觉信息。虽然神经解剖学和电生理学的研究已经提供了PbN到VPMpc的味觉投射的信息，但PbN和VPMpc之间的确切关系，特别是VPMpc到PbN的传出投射，尚不清楚。在此，我们研究了脲麻醉仓鼠这两种味觉传递之间的相互联系。我们记录了PbN中114个味觉反应神经元，并检测了它们对双侧VPMpc电刺激的反应性。对同侧或对侧VPMpc任一或两种刺激均可拮抗激活109个味觉PbN神经元。在双侧VPMpc刺激后，72个PbN神经元被拮抗激活，表明PbN中的味觉神经元对双侧VPMpc的响应较大。VPMpc刺激也激活了110个PbN神经元，包括106个VPMpc投射神经元。78个神经元被双侧正畸激活。在PbN细胞的正交激活中，抑制反应是主要的反应；106个细胞被抑制，其中10个神经元也被对侧兴奋，表明PbN中的味觉神经元受到VPMpc的强烈抑制控制。此外，VPMpc的刺激改变了PbN神经元的味觉反应，表明VPMpc调节了PbN神经元的味觉反应。这些结果可能提供了味觉加工和调节涉及这两个核的神经回路的功能见解。
The parvicellular part of the ventroposteromedial nucleus of the thalamus (VPMpc) is positioned at the key site between the gustatory parabrachial nuclei (PbN) and the gustatory cortex for relaying and processing gustatory information via the thalamocortical pathway. Although neuroanatomical and electrophysiological studies have provided information regarding the gustatory projection from PbN to VPMpc, the exact relationship between PbN and VPMpc, especially the efferent projection involving VPMpc to PbN, is obscure. Here we investigated the reciprocal connection between these two gustatory relays in urethane-anesthetized hamsters. We recorded from 114 taste-responsive neurons in the PbN and examined their responsiveness to electrical stimulation of the VPMpc bilaterally. Stimulation of either or both of the ipsilateral or contralateral VPMpc antidromically activated 109 gustatory PbN neurons. Seventy-two PbN neurons were antidromically activated after stimulation of both sides of the VPMpc, indicating that taste neurons in the PbN project heavily to the bilateral VPMpc. Stimulation of VPMpc also orthodromically activated 110 of PbN neurons, including 106 VPMpc projection neurons. Seventy-eight neurons were orthodromically activated bilaterally. Among orthodromic activations of the PbN cells, the inhibitory response was the dominant response; 106 cells were inhibited, including 10 neurons that were also excited contralaterally, indicating that taste neurons in the PbN are subject to strong inhibitory control from VPMpc. Moreover, stimulation of VPMpc altered taste responses of the neurons in the PbN, indicating that VPMpc modulates taste responses of PbN neurons. These results may provide functional insight of neural circuitry for taste processing and modulation involving these two nuclei.