DIFFERENT INFLUENCE OF SUPEROXIDE ANIONS AND HYDROGEN-PEROXIDE ON ENDOTHELIAL FUNCTION OF ISOLATED CAT CEREBRAL AND PULMONARY-ARTERIES
DIFFERENT INFLUENCE OF SUPEROXIDE ANIONS AND HYDROGEN-PEROXIDE ON ENDOTHELIAL FUNCTION OF ISOLATED CAT CEREBRAL AND PULMONARY-ARTERIES
复制标题
DOI：
10.1016/0306-3623(94)90138-4
复制
发表时间：
1994-10-01
期刊：
影响因子：
--
通讯作者：
DEPABLO, ALL
中科院分区：
文献类型：
--
作者：
FRAILE, ML;CONDE, MV;DEPABLO, ALL
1.外源性超氧化物歧化酶（SOD）或过氧化氢酶没有改变离体猫大脑中动脉基础张力。过氧化氢酶而非SOD可降低ACh的舒张作用. H2 O2诱导内皮非依赖性舒张反应，过氧化氢酶可阻断该反应. 3-氨基-1，2，4-三唑（AT）引起内皮依赖性收缩，ACh舒张减弱.二乙基二硫代氨基甲酸（DETC）诱导内皮非依赖性舒张，但不改变ACh的舒张作用. ACh对猫离体肺动脉的舒张作用不受SOD、过氧化氢酶和AT的影响，而受DETC的抑制.内皮过氧化氢酶参与EDRF的脑血管舒张作用，而H_2O_2参与ACh的舒张作用，SOD和超氧阴离子均不参与。在肺动脉中，只有内皮SOD活性起作用。
1. Exogenous superoxide dismutase (SOD) or catalase did not modify isolated cat middle cerebral arterial basal tone. Catalase but not SOD reduced ACh relaxation.2. H2O2 induced endothelium-independent relaxation which was abolished by catalase.3. 3-Amino-1,2,4-triazole (AT) evoked endothelium-dependent contractions and diminished ACh relaxation.4. Diethyldithio carbamic acid (DETC) induced endothelium-independent relaxation and did not modify ACh vasodilatation.5. ACh relaxation of cat isolated pulmonary arteries was unaffected by SOD, catalase or AT, and diminished by DETC.6. Endothelial catalase but neither SOD nor superoxide anions is involved in EDRF cerebral vasodilatation and H2O2 participates in ACh relaxation. In pulmonary arteries, only endothelial SOD activity plays a role.