Assessment of stiffness changes in the ex vivo porcine aortic wall using magnetic resonance elastography.
Assessment of stiffness changes in the ex vivo porcine aortic wall using magnetic resonance elastography.
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DOI：
10.1016/j.mri.2011.09.009
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发表时间：
2012-01
影响因子：
2.5
通讯作者：
Ehman, Richard L.
中科院分区：
文献类型：
--
作者：
Xu, Lei;Chen, Jun;Yin, Meng;Glaser, Kevin J.;Chen, Qingshan;Woodrum, David A.;Ehman, Richard L.
磁共振弹性成像（MRE）是一种非侵入性的相位对比技术，通过在组织内成像传播机械波来估计组织的力学特性。在这项研究中，我们假设福尔马林固定实验诱导的动脉壁刚度变化可以通过MRE在离体猪主动脉中测量。与我们的假设一致，MRE清楚地证明了样品固定后的显著刚度增加，并通过力学测试证实了这一点。结果表明，磁共振成像可用于检测主动脉的刚度变化。本研究为MRE直接评估主动脉壁硬度变化的有效性提供了证据。该结果为MRE作为一种无创的动脉壁力学性能评估方法提供了动力。
Magnetic resonance elastography (MRE) is a noninvasive phase-contrast technique for estimating the mechanical properties of tissues by imaging propagating mechanical waves within the tissue. In this study, we hypothesize that changes in arterial wall stiffness, experimentally induced by formalin fixation, can be measured using MRE in ex vivo porcine aortas. In agreement with our hypothesis, the significant stiffness increase after sample fixation were clearly demonstrated by MRE and confirmed by mechanical testing. The results indicate that MRE can be used to examine the stiffness changes of the aorta. This study has provided evidence of the effectiveness of using MRE to directly assess the stiffness change in aortic wall. The results offer motivation to pursue MRE as a noninvasive method for the evaluation of arterial wall mechanical properties.
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