Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential.
Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential.
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DOI：
10.1016/j.cell.2015.03.030
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发表时间：
2015-04-09
期刊：
影响因子：
64.5
通讯作者：
Allison JP
中科院分区：
文献类型：
--
作者：
Sharma P;Allison JP
两个方面的研究已经开发出为癌症患者带来显着益处的疗法。其中一个领域源于对激活或失活驱动癌症发展的信号通路的突变的详细了解。这项工作引发了靶向疗法的发展，使大多数携带靶向突变的患者产生临床反应，尽管反应通常持续时间有限。第二条前沿是分子免疫学的进展，揭示了调节细胞免疫反应机制的复杂性。这些进展导致成功靶向免疫检查点以释放抗肿瘤 T 细胞反应，从而产生持久的反应，但仅限于一小部分患者。在这篇综述中，我们讨论了这两个领域的研究进展，并提出将它们交叉并增加资金来指导药物组合的研究代表了为大多数癌症患者开发治疗方法的前进道路。
Research in two fronts has enabled the development of therapies that provide significant benefit to cancer patients. One area stems from a detailed knowledge of mutations that activate or inactivate signaling pathways that drive cancer development. This work triggered the development of targeted therapies that lead to clinical responses in the majority of patients bearing the targeted mutation, although responses are often of limited duration. In the second front are the advances in molecular immunology that unveiled the complexity of the mechanisms regulating cellular immune responses. These developments led to the successful targeting of immune checkpoints to unleash anti-tumor T cell responses, resulting in durable long-lasting responses but only in a fraction of patients. In this review we discuss the evolution of research in these two areas and propose that intercrossing them and increasing funding to guide research of combination of agents represent a path forward for the development of curative therapies for the majority of cancer patients.
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DOI：
10.1056/nejmoa1003466
发表时间：
2010-08-19
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hodi FS;O'Day SJ;McDermott DF;Weber RW;Sosman JA;Haanen JB;Gonzalez R;Robert C;Schadendorf D;Hassel JC;Akerley W;van den Eertwegh AJ;Lutzky J;Lorigan P;Vaubel JM;Linette GP;Hogg D;Ottensmeier CH;Lebbé C;Peschel C;Quirt I;Clark JI;Wolchok JD;Weber JS;Tian J;Yellin MJ;Nichol GM;Hoos A;Urba WJ
通讯作者：
Urba WJ
影响因子：
7.4
作者：
Brignone C;Gutierrez M;Mefti F;Brain E;Jarcau R;Cvitkovic F;Bousetta N;Medioni J;Gligorov J;Grygar C;Marcu M;Triebel F
通讯作者：
Triebel F
DOI：
10.1016/b978-0-12-397199-9.00001-x
发表时间：
2014-01-01
期刊：
ADVANCES IN INTELLIGENT VEHICLES
影响因子：
--
作者：
Chen, Yaobin;Li, Lingxi
通讯作者：
Li, Lingxi
DOI：
10.1056/nejmoa1200694
发表时间：
2012-06-28
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brahmer JR;Tykodi SS;Chow LQ;Hwu WJ;Topalian SL;Hwu P;Drake CG;Camacho LH;Kauh J;Odunsi K;Pitot HC;Hamid O;Bhatia S;Martins R;Eaton K;Chen S;Salay TM;Alaparthy S;Grosso JF;Korman AJ;Parker SM;Agrawal S;Goldberg SM;Pardoll DM;Gupta A;Wigginton JM
通讯作者：
Wigginton JM
DOI：
10.1084/jem.20130590
发表时间：
2014-04-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Fan X;Quezada SA;Sepulveda MA;Sharma P;Allison JP
通讯作者：
Allison JP