Bioresorbable optical sensor systems for monitoring of intracranial pressure and temperature
Bioresorbable optical sensor systems for monitoring of intracranial pressure and temperature
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DOI：
10.1126/sciadv.aaw1899
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发表时间：
2019-07-01
期刊：
影响因子：
13.6
通讯作者：
Rogers, John A.
中科院分区：
文献类型：
--
作者：
Shin, Jiho;Liu, Zhonghe;Rogers, John A.
颅内、眼内和血管内空间内的压力和温度的连续测量分别为创伤性脑损伤、青光眼和心血管疾病的治疗提供了重要的诊断信息。光学传感器由于其与磁共振成像（MRI）的固有兼容性而具有吸引力。现有的可植入光学部件使用永久性的不可吸收材料，使用后必须通过手术取出。这里介绍的生物可吸收替代品绕过了这一要求，从而消除了手术的成本和风险。在这里，毫米级生物可吸收法布里-珀罗干涉仪和二维光子晶体结构可以精确，连续地测量压力和温度。结合机械和光学模拟揭示了基本的传感机制。体外研究和组织病理学评价量化了这些系统的测量精度、使用寿命和生物相容性。体内演示确立了临床相关性能属性。这里概述的材料，设备设计和制造方法为不同类别的生物可吸收光学传感器建立了广泛的基础能力。
Continuous measurements of pressure and temperature within the intracranial, intraocular, and intravascular spaces provide essential diagnostic information for the treatment of traumatic brain injury, glaucoma, and cardiovascular diseases, respectively. Optical sensors are attractive because of their inherent compatibility with magnetic resonance imaging (MRI). Existing implantable optical components use permanent, nonresorbable materials that must be surgically extracted after use. Bioresorbable alternatives, introduced here, bypass this requirement, thereby eliminating the costs and risks of surgeries. Here, millimeter-scale bioresorbable Fabry-Perot interferometers and two dimensional photonic crystal structures enable precise, continuous measurements of pressure and temperature. Combined mechanical and optical simulations reveal the fundamental sensing mechanisms. In vitro studies and histopathological evaluations quantify the measurement accuracies, operational lifetimes, and biocompatibility of these systems. In vivo demonstrations establish clinically relevant performance attributes. The materials, device designs, and fabrication approaches outlined here establish broad foundational capabilities for diverse classes of bioresorbable optical sensors.