Corpus callosum integrity and neuropsychological performance after traumatic brain injury: a diffusion tensor imaging study.
Corpus callosum integrity and neuropsychological performance after traumatic brain injury: a diffusion tensor imaging study.
复制标题
DOI：
10.1097/htr.0b013e318289ede5
复制
发表时间：
2014-03
期刊：
影响因子：
--
通讯作者：
Ricker JH
中科院分区：
文献类型：
--
作者：
Arenth PM;Russell KC;Scanlon JM;Kessler LJ;Ricker JH
对DTI参数[各向异性分数（FA）和径向扩散率（RD）]进行详细分析，以评价胼胝体（CC）中的白色物质完整性，并检查DTI数据与认知功能多项指标之间的相关性。12名有复杂的轻度，中度或重度TBI病史的参与者和12名对照参与者完成了标准化和实验性神经心理学测试和FMRI会话，包括DTI。详细的DTI分析检查组间和组内比较DTI参数和人口统计学信息，以及情节记忆和执行功能的措施。组间存在差异，TBI组显示DTI值表明白色完整性降低，与损伤严重程度相关。两组都显示了DTI参数和认知测量之间的相关性，TBI组的相关性更显著。CC中的白色物质变化是明显的慢性，并与损伤的严重程度有关。DTI参数表明，白色物质的中断可能与TBI后认知任务和反应时间方面的表现受损有关。
To conduct a detailed analysis of DTI parameters [fractional anisotropy (FA) and radial diffusivity (RD)] to evaluate white matter integrity in the corpus callosum (CC), and to examine correlations between DTI data and performance on multiple measures of cognitive functioning. 12 participants with a history of complicated mild, moderate, or severe TBI, and 12 control participants completed both standardized and experimental neuropsychological testing and an FMRI session, including DTI. Detailed DTI analysis examined between-group and within-group comparisons of DTI parameters and demographic information, as well as measures of episodic memory and executive functioning. Differences were found between groups such that the TBI group demonstrated DTI values suggesting decreased white matter integrity, and correlations with injury severity. Both groups showed correlations between DTI parameters and cognitive measures, with more significant correlations observed for the TBI group. White matter changes in the CC were evident chronically, and were related to severity of injury. DTI parameters suggesting disruptions in white matter may be implicated in impaired performance, both in terms of cognitive tasks and reaction time, after TBI.