Transforming growth factor-beta and smooth muscle differentiation.
Transforming growth factor-beta and smooth muscle differentiation.
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DOI：
10.4331/wjbc.v3.i3.41
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发表时间：
2012-03-26
期刊：
影响因子：
--
通讯作者：
Chen, Shi-You
中科院分区：
文献类型：
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作者：
Guo, Xia;Chen, Shi-You
转化生长因子（TGF）-β家族成员是调节多种细胞功能如生长、粘附、迁移、凋亡和分化的多功能细胞因子。TGF-β通过特定的I型和II型丝氨酸/苏氨酸激酶受体和细胞内Smad转录因子引起其作用。 TGF-β信号通路不同组分的敲除小鼠模型已经揭示了它们在平滑肌细胞（SMC）分化中的关键作用。人类遗传学研究已经将这些信号成分的突变与特定的心血管疾病联系起来，如主动脉瘤和由于SMC缺陷引起的先天性心脏病。在这篇综述中，强调了目前对TGF-β在SMC分化中的功能的理解，并讨论了TGF-β信号在SMC相关疾病中的作用。
Transforming growth factor (TGF)-beta family members are multifunctional cytokines regulating diverse cellular functions such as growth, adhesion, migration, apoptosis, and differentiation. TGF-betas elicit their effects via specific type I and type II serine/threonine kinase receptors and intracellular Smad transcription factors. Knockout mouse models for the different components of the TGF-beta signaling pathway have revealed their critical roles in smooth muscle cell (SMC) differentiation. Genetic studies in humans have linked mutations in these signaling components to specific cardiovascular disorders such as aorta aneurysm and congenital heart diseases due to SMC defects. In this review, the current understanding of TGF-beta function in SMC differentiation is highlighted, and the role of TGF-beta signaling in SMC-related diseases is discussed.