Controlled modulation of all the arms of the immunity including innate immunity by biological response modifier glucans, a simple yet potential nutritional supplement strategy to fight <scp>COVID</scp> ‐19
Controlled modulation of all the arms of the immunity including innate immunity by biological response modifier glucans, a simple yet potential nutritional supplement strategy to fight <scp>COVID</scp> ‐19
复制标题
通过生物反应调节剂葡聚糖对所有免疫系统进行受控调节，包括先天免疫，这是一种简单但潜在的对抗 <scp>COVID</scp> 的营养补充策略 -19
DOI：
10.1111/jfbc.14156
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发表时间：
2022
影响因子：
4
通讯作者：
Abraham Samuel J. K.
中科院分区：
文献类型：
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作者：
Ikewaki Nobunao;Kurosawa Gene;Kisaka Tomohiko;Abraham Samuel J. K.
免疫调节是对抗COVID-19感染的潜在策略之一，重点是以平衡的方式增强先天免疫反应。β-葡聚糖被认为是非特异性免疫刺激佐剂，有助于增强保护性抗病毒免疫力。通过这篇文章，我们希望强调β-葡聚糖不仅能增强先天免疫力，而且还具有调节免疫力所有方面的能力，即，先天性、适应性、TRIM在不同的位点，包括那些被假定为SARS-CoV 2的进入位点。除了免疫调节能力，β葡聚糖的有益代谢和凝血相关作用，一种简单的营养补充策略，使它们被考虑用于更大规模的临床研究，以验证其预防性疫苗佐剂和基于营养的治疗补充剂活性，以有效对抗COVID-19大流行。实际应用只有当所有的武器，免疫系统以平衡和有效的方式发挥作用，这在COVID-19中尤为重要。基于其安全性跟踪记录及其对免疫系统所有分支的有益调节，使用生物反应调节剂β-葡聚糖（BRMG）进行营养补充值得考虑用于大规模临床研究。
Immune modulation, being one of the potential strategies to combat COVID‐19 infection, emphasis has been laid on enhancing the innate immune response in a balanced manner. Beta (β)‐glucans have been suggested as nonspecific immunostimulatory adjuvants to beneficially boost protective antiviral immunity. Through this article, we wish to emphasize that β‐glucans not only enhance the innate immunity but also possess the capability to modulate all the arms of the immunity viz., innate, adaptive, TRIM at different sites including those postulated to be the entry site of the SARS‐CoV2. Other than immune modulation capabilities, the beneficial metabolic‐ and coagulation‐related effects of β‐glucans, a simple nutritional supplementation strategy, make them be considered for larger clinical studies to validate their prophylactic vaccine adjuvant and nutritional‐based therapeutic supplement activities to effectively fight the COVID‐19 pandemic.Practical applicationsA 360° wholesome protection from viral infections is possible only when all the arms of the immune system function in a balanced and effective manner which is especially important in COVID‐19. Nutritional supplementation using biological response modifier beta (β)‐glucans (BRMGs) is worth considering for large‐scale clinical studies based on their track record of safety and their beneficial regulation of all the arms of the immune system.