CHARACTERISTICS OF MARROW PRODUCTION AND RETICULOCYTE MATURATION IN NORMAL MAN IN RESPONSE TO ANEMIA
CHARACTERISTICS OF MARROW PRODUCTION AND RETICULOCYTE MATURATION IN NORMAL MAN IN RESPONSE TO ANEMIA
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DOI：
10.1172/jci106001
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发表时间：
1969-01-01
影响因子：
15.9
通讯作者：
HILLMAN, RS
中科院分区：
文献类型：
--
作者：
HILLMAN, RS
研究了正常人在不同严重程度的放血诱发贫血期间的红细胞生成。本研究允许在广泛的骨髓生成水平范围内比较骨髓生成测量值。只要血清铁保持在50 μg/100 ml以上，血浆铁周转率的测量提供了一个很好的指标，骨髓生产在所有水平的红细胞生产。相反，网织红细胞绝对计数与其他测量值的相关性较差。这被证明是循环网织红细胞失去其网织红细胞所需时间延长的结果，这与贫血的严重程度相关。对于网织红细胞计数作为骨髓产生测量的临床应用，必须对循环网织红细胞成熟时间的这种改变进行调整。
Erythropoiesis in normal man was studied during periods of phlebotomy-induced anemia of varying severity. This study permitted a comparison of marrow production measurements over a wide range of marrow production levels. As long as the serum iron remained above 50 μg/100 ml, measurements of plasma iron turnover provided an excellent index of marrow production at all levels of red cell production. In contrast, the absolute reticulocyte count demonstrated a poor correlation with the other measurements. This was shown to be the result of a prolongation of the time required for circulating reticulocytes to lose their reticulum, which correlated with the severity of the anemia. For the clinical application of the reticulocyte count as a measurement of marrow production, an adjustment must be made for this alteration in the circulating reticulocyte maturation time.