Environmental exposure to BDE47 is associated with increased diabetes prevalence: Evidence from community-based case-control studies and an animal experiment.
Environmental exposure to BDE47 is associated with increased diabetes prevalence: Evidence from community-based case-control studies and an animal experiment.
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BDE47 的环境暴露与糖尿病患病率增加有关：来自社区病例对照研究和动物实验的证据
DOI：
10.1038/srep27854
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发表时间：
2016-06-13
影响因子：
4.6
通讯作者：
Wang SL
中科院分区：
文献类型：
--
作者：
Zhang Z;Li S;Liu L;Wang L;Xiao X;Sun Z;Wang X;Wang C;Wang M;Li L;Xu Q;Gao W;Wang SL
溴化阻燃剂的暴露与糖尿病和代谢性疾病的增加趋势有关。因此，这项研究的目的是提供多溴二苯醚(PBDEs)暴露与糖尿病患病率相关的证据，并揭示流行病学和动物研究中潜在的潜在机制。所有参与者在2011年至2012年在中国进行的两项独立社区研究中接受了问卷调查、健康检查和血清中7种多溴联苯醚同系物的检测。将雄性大鼠暴露于2，2‘，4，4’-四溴二苯醚(BDE47)8周，用高通量基因组分析方法探讨BDE47对血糖稳态的影响及其可能的机制。在研究I和研究II中，研究I和研究II中每三分位数的苯并二恶英暴露显著增加糖尿病患病率(P趋势= 0.001)和研究II(P趋势= 0.001)。此外，BDE47治疗可引起大鼠高血糖。此外，基因芯片分析显示，糖尿病途径和涉及葡萄糖转运的三个基因本体论术语得到了丰富。结果表明，环境中暴露于BDE47与糖尿病患病率的增加有关。然而，与BDE47相关的糖尿病的病因还需要进一步的前瞻性和机械性研究。
Brominated flame retardants exposure has been associated with increasing trends of diabetes and metabolic disease. Thus, the purpose of this study was to provide evidence of polybrominated diphenyl ethers (PBDEs) exposure in relation to diabetes prevalence and to reveal the potential underlying mechanism in epidemiological and animal studies. All the participants received a questionnaire, health examination, and the detection of 7 PBDE congeners in serum in two independent community-based studies from 2011 to 2012 in China. Male rats were exposed to 2,2’4,4’-tetrabromodiphenyl ether (BDE47) for 8 weeks to explore its effects on glucose homeostasis and potential mechanisms using high-throughput genomic analysis. Among the 7 congeners, BDE47 showed significant high detection rate and concentration in cases in Study I and Study II. Every tertile of BDE47 exposure significantly increased the risk of diabetes prevalence in Study I (Ptrend= 0.001) and Study II (Ptrend< 0.001). Additionally, BDE47 treatments induced hyperglycemia in rats. Furthermore, gene microarray analysis showed that diabetes pathway and three gene ontology terms involved in glucose transport were enriched. The results indicated that environmental exposure to BDE47 was associated with increased diabetes prevalence. However, further prospective and mechanistic studies are needed to the causation of diabetes in relation to BDE47.