P53 PROTEIN EXPRESSION IN PUTATIVE PRECURSOR LESIONS OF EPITHELIAL OVARIAN-CANCER
P53 PROTEIN EXPRESSION IN PUTATIVE PRECURSOR LESIONS OF EPITHELIAL OVARIAN-CANCER
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DOI：
10.1111/j.1365-2559.1995.tb01528.x
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发表时间：
1995-10-01
期刊：
影响因子：
6.4
通讯作者：
WELLS, M
中科院分区：
文献类型：
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作者：
HUTSON, R;RAMSDALE, J;WELLS, M
研究了P53蛋白在卵巢浆液性癌旁和对侧上皮包涵囊肿中的表达，并将其与交界性肿瘤相关的上皮包涵囊肿和正常卵巢中的表达进行了比较。在13例晚期（III期）浆液性卵巢癌中，有8例发现上皮包涵囊肿有异型性。在这8例非典型上皮包涵性囊肿中，5例显示p53的免疫反应性。在交界性肿瘤和正常卵巢中未发现此类囊肿的异型性，p53在卵巢浆液性腺癌相关的表面上皮中的表达（13例中的10例）也比在正常卵巢中的表达（13例中的1例）更为频繁。我们假设上皮包涵性囊肿的异型性（卵巢上皮内瘤变）病灶区域是卵巢恶性肿瘤的前兆。至少在某些情况下，p53蛋白表达可能先于明显的细胞学异常。
p53 protein expression has been studied in epithelial inclusion cysts adjacent to and contralateral to serous carcinoma of the ovary and compared to epithelial inclusion cysts associated with borderline tumours and in normal ovaries. Atypia was found in epithelial inclusion cysts in eight of the thirteen advanced (stage III) serous ovarian carcinomas. Of these eight with atypical epithelial inclusion cysts, five showed immunoreactivity for p53, In the borderline tumours and normal ovaries no atypia in such cysts was found, p53 expression was also seen more frequently in surface epithelium associated with ovarian serous adenocarcinoma (ten of 13) than in normal ovaries (one of 13). We postulate that focal areas of atypia (ovarian intra-epithelial neoplasia) in epithelial inclusion cysts are the precursors of ovarian malignancy. In some cases, at least, p53 protein expression may precede overt cytological abnormalities.