Matrix metalloproteinase genes in Xenopus development
Matrix metalloproteinase genes in Xenopus development
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DOI：
10.1002/dvdy.20113
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发表时间：
2004-09-01
影响因子：
2.5
通讯作者：
Wheeler, GN
中科院分区：
文献类型：
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作者：
Harrison, M;Abu-Elmagd, M;Wheeler, GN
基质金属蛋白酶(MMPs)是脊椎动物中的一个蛋白质大家族，在人类中由24个以上的基因组成，其中只有很少的基因在非洲爪哇被发现。目前已鉴定出三个非洲爪哇MMPs编码基因，并对其在发育过程中的表达进行了研究。膜结合型XMMP14和XMMP15(XMT1-MMP1和XMT2-MMP2)均表现出限制性表达模式，前者主要定位于脑神经脊组织，后者主要定位于胚胎的表皮。XMMP-7编码的是一种缺少类血凝蛋白结构域的基质金属蛋白酶。它只在巨噬细胞或其他发育早期的髓系细胞中表达。(C)2004年Wiley-Liss公司
Matrix metalloproteinases (MMPs) are a large family of proteins in vertebrates, consisting of over 24 genes in humans, only a few of which have been identified in Xenopus. Three genes coding for MMPs in Xenopus have been identified and their expression studied during development. The membrane-bound XMMP-14 and -15 (XMT1-MMP and XMT2-MMP) both showed restricted expression patterns, the former principally localising to cranial neural crest tissues and the latter to the epidermis of the embryo. XMMP-7 codes for an MMP that lacks the hemopexin-like domain. It is expressed exclusively in macrophages; or other myeloid cell types from early in development. (C) 2004 Wiley-Liss, Inc.