ELEVATED PLATELET CALCIUM MOBILIZATION AND NITRIC-OXIDE SYNTHASE ACTIVITY MAY REFLECT ABNORMALITIES IN SCHIZOPHRENIC BRAIN
ELEVATED PLATELET CALCIUM MOBILIZATION AND NITRIC-OXIDE SYNTHASE ACTIVITY MAY REFLECT ABNORMALITIES IN SCHIZOPHRENIC BRAIN
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DOI：
10.1006/bbrc.1995.1980
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发表时间：
1995-07-17
影响因子：
3.1
通讯作者：
HIRSCH, SR
中科院分区：
文献类型：
--
作者：
DAS, I;KHAN, NS;HIRSCH, SR
精神分裂症有不同的临床症状，并提出了一些假设来解释其病因学基础。在这项研究中，我们研究了两个方面的膜功能，受体激活的钙动员和钙激活的一氧化氮合酶活性在精神分裂症的主题。凝血酶诱导钙离子从细胞内库中动员。药物初治精神分裂症患者的血小板反应被认为是显着增加的凝血酶浓度范围（0.01至0.60 U/ml）相比，对照组。一氧化氮（NO）可能参与精神分裂症的病因进行了调查。NO在功能上与多巴胺能和多巴胺能系统都有联系，这两个系统都与精神分裂症的生化病理学密切相关。一氧化氮合酶（NOS）活性测定对照组，精神分裂症和惊恐障碍受试者的血小板。与对照组、药物治疗的精神分裂症患者和惊恐障碍患者相比，未用药的精神分裂症患者血小板中的酶活性显著升高。提示精神分裂症患者血小板中钙诱导的L-精氨酸-一氧化氮途径存在失衡，可通过抗精神病药物治疗进行调节。这种不平衡可能反映在中枢神经系统中，特别是在NMDA受体上。这是可能的，这种干扰L-精氨酸-一氧化氮途径可能有病理意义的精神分裂症的病因。(C)出版社：Academic Press
Schizophrenia has a diverse nature of clinical symptoms and a number of hypotheses have been suggested to explain its aetiological basis. In this study we have examined two aspects of membrane function, receptor-activated calcium mobilization and calcium activated nitric oxide synthase activity in schizophrenic subjects. Thrombin induces mobilization of calcium ions from intracellular stores. The platelet response of drug naive schizophrenics was found to be significantly increased over a range of thrombin concentrations (0.01 to 0.60 U/ml) compared to control subjects. Possible involvement of nitric oxide (NO) in the aetiology of schizophrenia was investigated. NO has been functionally linked to both dopaminergic and glutamatergic systems both of which are strongly implicated in the biochemical pathology of schizophrenia. Nitric oxide synthase (NOS) activity was determined in platelets of controls, schizophrenic and panic disorder subjects. Enzyme activity was found to be significantly higher in platelets of drug naive schizophrenic subjects compared to controls, drug treated schizophrenics and panic disorder subjects. It is suggested that there is an imbalance of the calcium-induced L-arginine- nitric oxide pathway in platelets of schizophrenic subjects which may be modified by neuroleptic treatment. This imbalance may be mirrored in the central nervous system in particular at the NMDA receptor. It is possible that such a disturbance in the L-arginine-nitric oxide pathway may have pathological implications in the aetiology of schizophrenia. (C) 1995 Academic Press, Inc.