Relationship of sphincter of Oddi spike bursts to gastrointestinal myoelectric activity in conscious opossums.
Relationship of sphincter of Oddi spike bursts to gastrointestinal myoelectric activity in conscious opossums.
复制标题
清醒负鼠奥狄括约肌尖峰爆发与胃肠道肌电活动的关系。
DOI：
10.1172/jci110515
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Itoh,Z
中科院分区：
文献类型：
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作者：
Honda,R;Toouli,J;Dodds,WJ;Sarna,S;Hogan,WJ;Itoh,Z
对负鼠Oddi括约肌（SO）表现出蠕动棘波爆发，伴随着收缩波，起源于近端的Oddi括约肌，并向十二指肠传播。在这项研究中，我们记录肌电活动的负鼠SO和上消化道在六个清醒的动物使用长期植入电极。将双极电极植入胃窦、十二指肠、SO段、空肠和回肠。在禁食期间，SO棘波爆发的频率（以每分钟的数量计）显示出由四个阶段（A至D）组成的循环模式。A相有一个低的棘波爆发频率为102/min，持续1020 min。在B相，棘波爆发频率逐渐增加，在40-45 min的时间间隔内达到高潮，在C相活动的一个短的时间间隔，其特征是最大的棘波爆发频率为105/min。在D相，棘波爆发下降超过15 min，合并与A相的低频率和重复的周期。SO周期的周期长度为87±11 SD min，与上消化道移行性复合肌电（MMC）的周期长度基本一致。SO中C相活动的开始时间比十二指肠中MMC活动的第III相早1-2分钟。喂食取消了在SO以及在上消化道的尖峰爆发活动的周期性模式。喂食后，SO峰电位爆发以5-6次/min的频率发生，持续至少3 h。我们的结论是：（a）在禁食期间，对抗负鼠SO的锋电位爆发频率表现出周期性变化;（b）SO的最大锋电位爆发频率几乎与III期MMC活性通过十二指肠同时发生;（B）进食消除了SO的消化间隙周期性锋电位爆发模式以及胃肠道的模式。
The oppossum sphincter of Oddi (SO) exhibits peristaltic spike bursts with accompanying contraction waves that originate proximally in the sphincter of Oddi and propagate toward the duodenum. In this study we recorded myoelectrical activity of the opossum SO and upper gastrointestinal tract in six conscious animals using chronically implanted electrodes. Biopolar electrodes were implanted in the gastric antrum, duodenum, SO segment, jejunum, and ileum. During fasting the frequency of SO spike bursts, scored as number per minute, showed a cyclic pattern consisting of four phases (A to D). Phase A had a low spike burst frequency of ∼2/min that lasted ∼20 min. In phase B, the spike burst frequency increased progressively during a 40-45 min interval culminating in a short interval of phase C activity characterized by a maximal spike burst frequency of ∼5/min. During phase D, the spike bursts decreased over 15 min to merge with the low frequency of phase A and the cycle repeated. Cycle length of the interdigestive SO cycle, 87±11 SD min, was virtually identical with that of the interdigestive migrating myoelectric complex (MMC) of the upper gastrointestinal tract. The onset of phase C activity in the SO began 1-2 min before phase III of the MMC activity in the duodenum. Feeding abolished the cyclic pattern of spike burst activity in the SO as well as in the upper gastrointestinal tract. After feeding the SO spike bursts occurred at a frequency of 5-6/min for at least 3 h. We conclude that: (a) During fasting, the oppossum SO exhibits cyclic changes in its spike burst frequency; (b) Maximal spike burst frequency of the SO occurs virtually concurrent with passage of phase III MMC activity through the duodenum and; (c) Feeding abolishes the interdigestive cyclic spike burst pattern of the SO as well as that of the gastrointestinal tract.