Experimental induction of atheroarteriosclerosis by the synergy of allergic injury to arteries and lipid-rich diet. II. Effect of repeatedly injected foreign protein in rabbits fed a lipid-rich, cholesterol-poor diet.
Experimental induction of atheroarteriosclerosis by the synergy of allergic injury to arteries and lipid-rich diet. II. Effect of repeatedly injected foreign protein in rabbits fed a lipid-rich, cholesterol-poor diet.
复制标题
通过动脉过敏性损伤和高脂饮食的协同作用实验性诱导动脉粥样硬化。
DOI：
--
复制
发表时间：
1973
影响因子：
6
通讯作者：
Murphy Ge
中科院分区：
文献类型：
--
作者：
Minick Cr;Murphy Ge
在长达17个月的时间里，喂食富含脂质、低胆固醇的饮食并同时注射外源蛋白的兔子的冠状动脉出现了两种情况：a)增生性纤维肌肉内膜增厚，与人类冠状动脉中常见的弥漫性内膜增厚非常相似；b)脂肪增生性纤维肌肉内膜增厚，与人类冠状动脉粥样硬化非常相似。相比之下，另一组兔子同时喂食相同的食物长达22个月而不注射外来蛋白质，它们的心脏动脉发生了变化，既不像冠状动脉粥样硬化，也不像人类的弥漫性内膜增厚。与后一组相比，第一组兔子的主动脉脂肪增生性变化明显更大，更接近于人类主动脉粥样硬化。在实验过程中，两组家兔的平均血清胆固醇水平无显著差异。大约是200到250毫克，这是美国成年人血清胆固醇的平均水平。这些实验支持了一种假设，即动脉损伤，特别是免疫损伤，与富含脂质饮食的协同作用可导致人类动脉粥样硬化。
Rabbits fed a lipid-rich, cholesterol-poor diet and given concomitant injections of foreign protein, over a period as long as 17 months, developed in their coronary arteries both a) proliferative fibromuscular intimal thickening closely resembling the diffuse intimal thickening that commonly occurs in coronary arteries of man, and b) fatty-proliferative fibromuscular intimal thickening that closely resembles coronary atherosclerosis in man. In contrast, rabbits of another group that were concurrently fed the same diet for as long as 22 months without injections of foreign protein developed changes in arteries of their hearts that resemble neither coronary atherosclerosis nor diffuse intimal thickening in man. Fatty-proliferative changes in aortas of the first group of rabbits are strikingly greater and more closely resemble human aortic atherosclerosis than those in the latter group. In the course of the experiments, the average serum cholesterol was not significantly different in the two groups of rabbits. It was approximately 200 to 250 mg%, which is the average serum cholesterol in adult humans in the United States. These experiments support the hypothesis that the synergy of arterial injury, in particular immunologic injury, and a diet rich in lipid can lead to atherosclerosis in man.