Characteristics of non-responders and the impact of non-response on prevalence estimates of dementia
Characteristics of non-responders and the impact of non-response on prevalence estimates of dementia
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DOI：
10.1093/ije/26.5.1055
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发表时间：
1997-10-01
影响因子：
7.7
通讯作者：
VanTilburg, W
中科院分区：
文献类型：
--
作者：
Boersma, F;Eefsting, JA;VanTilburg, W
背景应答者和非应答者的社会人口学特征和认知功能障碍的差异分布可能导致仅基于应答者的痴呆患病率估计存在偏倚。应答者（n = 2191）的横断面，两阶段社区研究进行了比较，关于社会人口特征和认知与三个亚组的无应答者：（A）拒绝参加的受试者（n = 369），（B）筛选前病情严重或死亡的受试者（n = 72）和（C）已搬出研究区域或无法追踪的受试者（n = 23）。对应答者的年龄和住房情况的患病率估计值以及医生对认知障碍的评分用于估计无应答者中痴呆的患病率。A组在年龄和住房情况上与应答者不同，B组在年龄、住房和认知上与应答者不同，C组仅在年龄上与应答者不同。根据年龄、住房和认知能力对痴呆症患病率的单独估计，A组的患病率在4.9%至7.2%之间，B组在13.1%至19.1%之间，C组在2.6%至4.2%之间。结合应答者的患病率（6.5%），目标人群中痴呆患病率的最佳可能点估计值介于6.4%和6.9%之间，即在应答者患病率（5.4-7.5%）的95%置信区间（CI）内。虽然在本研究中，无应答对总体患病率没有重要影响，但不同无应答亚组的结果表明，从社会人口统计学角度以及研究目的方面描述无应答的重要性。作者建议根据无应答的原因将无应答者分为不同的组。
Background. Differential distributions of sociodemographic characteristics and cognitive impairment in responders and non-responders may result in a biased prevalence estimate of dementia based on responders only,Methods. Responders (n = 2191) to a cross-sectional, two-stage community study were compared with regard to sociodemographic characteristics and cognition with three subgroups of non-responders: (A) subjects who refused to participate (n = 369), (B) subjects who were too ill or who had died prior to the screening (n = 72) and (C) subjects who had moved out of the study region or were not traceable (n = 23). Prevalence estimates specific for age and housing situation in responders and physicians' ratings of cognitive impairment were used to estimate the prevalence of dementia among non-responders.Results. Group A differed from responders in age and housing situation, group B in age, housing and cognition, and group C only in age. Separate prevalence estimates of dementia based on age, housing and cognition yielded figures for group A between 4.9% and 7.2%, for group B between 13.1% and 19.1%, and for group C between 2.6% and 4.2%. Joined with the prevalence rate among responders (6.5%) the best possible point estimate of the prevalence of dementia in the target population lies between 6.4% and 6.9%, i.e. within the 95% confidence interval (CI) of the prevalence among responders (5.4-7.5%).Conclusions. Although in this study non-response had no important influence on the overall prevalence, the findings among the distinct non-response subgroups point to the importance of describing non-response sociodemographically as well as in terms of the study objective. The authors recommend that non-responders are categorized into distinct groups based on the reason for non-response.