Current Progress in the Rejuvenation of Aging Stem/Progenitor Cells for Improving the Therapeutic Effectiveness of Myocardial Repair.
Current Progress in the Rejuvenation of Aging Stem/Progenitor Cells for Improving the Therapeutic Effectiveness of Myocardial Repair.
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DOI：
10.1155/2018/9308301
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发表时间：
2018
影响因子：
4.3
通讯作者：
Cai C
中科院分区：
文献类型：
--
作者：
Kaur G;Cai C
缺血性心脏病影响大多数人，尤其是老年患者。最近的研究已经利用自体成体干/祖细胞作为治疗选择来治愈心肌梗死后的心脏组织。然而，来自老年患者的供体细胞更有可能处于衰老阶段。返老还童是逆转衰老造成的损害和促进年轻表型所必需的。这篇综述的目的是讨论目前的策略，是有效的再生老化的心脏干细胞和代表新的治疗方法来治疗老化的心脏。最近的文献主要集中在三种旨在逆转心脏衰老的方法：遗传修饰，药物管理和细胞外因子的优化。体外遗传修饰可用于过表达或敲低某些基因，并允许逆转衰老表型。药物施用是允许操纵与细胞增殖和细胞衰老相关的信号传导途径的另一种方法。由于干细胞小生境可能导致干细胞功能的年龄相关性下降，因此复壮策略还包括细胞外因子的优化。总的来说，改善衰老干细胞的内在特性以及周围环境可以使这些细胞采用与年轻干细胞相似的表型。
Ischemic heart disease affects a majority of people, especially elderly patients. Recent studies have utilized autologous adult stem/progenitor cells as a treatment option to heal cardiac tissue after myocardial infarction. However, donor cells from aging patients are more likely to be in a senescent stage. Rejuvenation is required to reverse the damage levied by aging and promote a youthful phenotype. This review aims to discuss current strategies that are effective in rejuvenating aging cardiac stem cells and represent novel therapeutic methods to treat the aging heart. Recent literature mainly focuses on three approaches that aim to reverse cardiac aging: genetic modification, pharmaceutical administration, and optimization of extracellular factors. In vitro genetic modification can be used to overexpress or knock down certain genes and allow for reversal of the aging phenotype. Pharmaceutical administration is another approach that allows for manipulation of signaling pathways related to cell proliferation and cell senescence. Since the stem cell niche can contribute to the age-related decline in stem cell function, rejuvenation strategies also include optimization of extracellular factors. Overall, improving the intrinsic properties of aging stem cells as well as the surrounding environment allows these cells to adopt a phenotype similar to their younger counterparts.
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影响因子：
11.1
作者：
Carlson, Morgan E.;Suetta, Charlotte;Conboy, Michael J.;Aagaard, Per;Mackey, Abigail;Kjaer, Michael;Conboy, Irina
通讯作者：
Conboy, Irina
影响因子：
64.5
作者：
Bersell, Kevin;Arab, Shima;Kuehn, Bernhard
通讯作者：
Kuehn, Bernhard
影响因子：
4.9
作者：
Gao, Xiao-Ming;Wong, Geoffrey;Du, Xiao-Jun
通讯作者：
Du, Xiao-Jun
DOI：
10.1073/pnas.1206432109
发表时间：
2012-10-23
影响因子：
11.1
作者：
Bernardo, Bianca C.;Gao, Xiao-Ming;McMullen, Julie R.
通讯作者：
McMullen, Julie R.
影响因子：
64.8
作者：
Conboy, IM;Conboy, MJ;Rando, TA
通讯作者：
Rando, TA