Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases.
Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases.
复制标题
与年龄和疾病相关的肌肉损失：糖尿病、肥胖和其他疾病的影响。
DOI：
10.1016/s2213-8587(14)70034-8
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发表时间：
2014-10
影响因子：
44.5
通讯作者：
Ferrucci, Luigi
中科院分区：
文献类型：
--
作者：
Kalyani, Rita Rastogi;Corriere, Mark;Ferrucci, Luigi
肌肉减少症指的是随着年龄增长而出现的肌肉量减少。基于研究结果显示肌肉质量与功能结果仅存在中度相关性，国际工作组提出，肌肉力量或身体功能的丧失也应纳入定义。无论如何定义肌肉减少症，随着年龄的增长，肌肉质量低和肌肉力量差显然是非常普遍和重要的残疾和潜在死亡风险因素。除衰老外，许多慢性疾病也可能加速肌肉质量和力量的减少，这种影响可能是慢性疾病导致身体残疾的主要潜在机制。在这篇综述中，我们讨论了与年龄相关和与疾病相关的肌肉损失，重点是糖尿病和肥胖，但包括其他疾病状态，以及潜在的共同机制和治疗方法。开发治疗与年龄有关和与疾病有关的肌肉损失的方法，可能会改善老年人的积极预期寿命，并导致大量的保健储蓄和生活质量的提高。
The term sarcopenia refers to the loss of muscle mass that occurs with ageing. On the basis of study results showing that muscle mass is only moderately related to functional outcomes, international working groups have proposed that loss of muscle strength or physical function should also be included in the definition. Irrespective of how sarcopenia is defined, both low muscle mass and poor muscle strength are clearly highly prevalent and important risk factors for disability and potentially mortality in individuals as they age. Many chronic diseases, in addition to ageing, could also accelerate decrease of muscle mass and strength, and this effect could be a main underlying mechanism by which chronic diseases cause physical disability. In this Review, we address both age-related and disease-related muscle loss, with a focus on diabetes and obesity but including other disease states, and potential common mechanisms and treatments. Development of treatments for age-related and disease-related muscle loss might improve active life expectancy in older people, and lead to substantial health-care savings and improved quality of life.